{"id":"W2290324741","doi":"10.1093/hmg/ddw027","title":"Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Simon Fraser University; Canadian Centre for Applied Research in Cancer Control; Public Health Ontario; BC Centre for Disease Control; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Center for Chronic Disease Prevention and Health Promotion; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Council NSW; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Leukemia and Lymphoma Research; National Health and Medical Research Council; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; University of Pittsburgh; Stockholms Läns Landsting; University of Utah; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; Bundesministerium für Bildung und Forschung; U.S. Department of Health and Human Services; University of California, San Francisco; Michael Smith Health Research BC; National Institute on Aging; Health Research Board; National Cancer Research Institute; Huntsman Cancer Institute; José Carreras Leukämie-Stiftung; Yale University; Karolinska Institutet; Utah State University; Wake Forest University; Ohio State University; University of Sydney; World Health Organization; University of Southern California; Cancer Research UK; American Cancer Society; National Human Genome Research Institute; Cancer Council Victoria; Compagnia di San Paolo; U.S. Department of Veterans Affairs; European Commission; Utah Department of Health; Brigham and Women's Hospital; Memorial Sloan-Kettering Cancer Center","keywords":"Telomere; Chronic lymphocytic leukemia; Lymphoma; Odds ratio; Biology; Genotype; Follicular lymphoma; Single-nucleotide polymorphism; Oncology; Internal medicine; Immunology; Genetics; Leukemia; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002072159,0.000392656,0.0006011077,0.0002056162,0.0001134269,0.0000201869,0.0002740548,0.0002720682,0.0003253206],"category_scores_gemma":[0.0002151054,0.0002753743,0.0001801533,0.0003689549,0.0004382891,0.00003267743,0.00008248675,0.0001428735,0.00003279624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000904031,"about_ca_system_score_gemma":0.0002826762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006048015,"about_ca_topic_score_gemma":0.00003706276,"domain_scores_codex":[0.9973042,0.0001957101,0.0005692993,0.0005891823,0.0007925568,0.0005490709],"domain_scores_gemma":[0.9977245,0.0001180683,0.0003446763,0.0009142571,0.0005261045,0.0003723927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003109543,0.001157804,0.1719526,0.00009996071,0.0005925097,0.0003424234,0.0003776601,0.000004304547,0.8180144,0.00007377406,0.0006261708,0.00644747],"study_design_scores_gemma":[0.006348155,0.001175411,0.5699212,0.0002659981,0.0006782699,0.0000304903,0.00003905781,0.0000850955,0.4205048,0.0001356678,0.000444508,0.0003713765],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995647,0.001069953,0.001054707,0.00007997056,0.00004158889,0.0004935809,0.000168389,0.000113152,0.001331631],"genre_scores_gemma":[0.9962339,0.0004876484,0.002134029,0.0004017892,0.00006392779,0.0000164614,0.00005889952,0.0001068151,0.0004965761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3979686,"threshold_uncertainty_score":0.9999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008547912533676864,"score_gpt":0.2209914208163234,"score_spread":0.2124435082826466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}