{"id":"W2290385391","doi":"10.1021/acsmedchemlett.5b00359","title":"Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics","year":2015,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Vlaamse regering; Narodowe Centrum Nauki; Ministerstwo Edukacji i Nauki; Fonds Wetenschappelijk Onderzoek","keywords":"Pharmacology; Opioid; Buprenorphine; Antagonist; Analgesic; Morphine; Agonist; Neuropathic pain; Pharmacophore; Chemistry; Medicine; Nociception; Receptor; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005060476,0.0002433429,0.0003192564,0.00002731386,0.00009008554,0.00003286031,0.0002626076,0.00007163944,0.00001378227],"category_scores_gemma":[0.0008702344,0.0002226518,0.00005144201,0.000159633,0.0005549076,0.00009485553,0.0001304826,0.0003519566,0.000008196438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002323988,"about_ca_system_score_gemma":0.00005401766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001203787,"about_ca_topic_score_gemma":1.529815e-7,"domain_scores_codex":[0.9980481,0.0003053225,0.0003683619,0.0005237253,0.0004214874,0.000333007],"domain_scores_gemma":[0.9987937,0.0004057418,0.0002449,0.0002722705,0.00004649547,0.0002369087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001556857,0.00005145994,0.0001917516,0.00007312749,0.000008959196,0.0002071189,0.0001673168,0.000003706761,0.9891083,0.00001597171,0.009541885,0.0004747674],"study_design_scores_gemma":[0.0009366602,0.0002809276,0.0002001684,0.00003149414,0.00005640855,0.0001966774,0.00006825584,0.0001831871,0.9923931,0.00004521113,0.005397258,0.0002106409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967334,0.00003751243,0.00007917382,0.002444343,0.0001415118,0.0001109584,0.00005231811,0.00005069667,0.0003500682],"genre_scores_gemma":[0.9909808,0.0001140351,0.00004454355,0.008441569,0.0002290049,0.000006172733,0.00002760282,0.00003280821,0.0001234835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005997226,"threshold_uncertainty_score":0.9079475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02170136707805061,"score_gpt":0.2456183724650962,"score_spread":0.2239170053870456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}