{"id":"W2290385391","doi":"10.1021/acsmedchemlett.5b00359","title":"Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics","year":2015,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Vlaamse regering; Narodowe Centrum Nauki; Ministerstwo Edukacji i Nauki; Fonds Wetenschappelijk Onderzoek","keywords":"Pharmacology; Opioid; Buprenorphine; Antagonist; Analgesic; Morphine; Agonist; Neuropathic pain; Pharmacophore; Chemistry; Medicine; Nociception; Receptor; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008770257,0.0003070014,0.0003860693,0.0001287483,0.0001094726,0.0001983419,0.0001992025,0.0002099758,0.001068921],"category_scores_gemma":[0.00007989556,0.0001114266,0.0001637625,0.0001288541,0.0001156883,0.0002504237,0.0001860508,0.0005146641,0.0002666088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597703,"about_ca_system_score_gemma":0.0001683465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001654121,"about_ca_topic_score_gemma":0.0005739549,"domain_scores_codex":[0.9999191,0.00001190922,0.000008196742,0.00001192933,0.00002277924,0.0000260565],"domain_scores_gemma":[0.9999733,0.000002746531,0.000007767723,0.000001863537,0.000003586301,0.00001078481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002626754,0.00006072449,0.00004096691,0.0000890228,0.000006183026,0.0001091249,0.00001432842,0.000129982,0.995209,0.0001581766,0.00004940451,0.003870304],"study_design_scores_gemma":[0.0001257202,0.00240589,0.001310023,0.00001022422,0.00003070255,0.0006195944,0.00001876379,0.0007269438,0.991032,0.00006897133,0.003638814,0.00001243346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885356,0.003213804,0.004848097,0.0001021811,0.00005341452,0.00008416132,0.0003845924,0.00006068911,0.002717622],"genre_scores_gemma":[0.9892574,0.00234035,0.005749964,0.00008213409,0.00001772011,0.00006456752,0.000384302,0.00001309285,0.002090531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068921,"threshold_uncertainty_score":0.003575921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02170136707805061,"score_gpt":0.2456183724650962,"score_spread":0.2239170053870456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}