{"id":"W2290513946","doi":"10.1021/acschembio.5b01070","title":"Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Institute of Infection and Immunity; Canada Research Chairs","keywords":"Tobramycin; Aminoglycoside; Resistome; Gentamicin; Antibiotics; Microbiology; Biology; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003377621,0.000124198,0.0002579731,0.00004863587,0.0000582079,0.000008773092,0.000252015,0.0003100047,0.00000718609],"category_scores_gemma":[0.001431993,0.00007030638,0.0002112097,0.0001808826,0.0004403873,0.000003727668,0.0001846096,0.00007415213,8.354333e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001291218,"about_ca_system_score_gemma":0.00004160726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006254842,"about_ca_topic_score_gemma":0.00001167596,"domain_scores_codex":[0.9987258,0.0001635021,0.0003827728,0.0004201856,0.00007397806,0.0002337077],"domain_scores_gemma":[0.9989972,0.0003110236,0.00012081,0.0003520006,0.0001365087,0.00008242164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001313614,0.00002050296,0.004413961,0.000005375765,0.0002883237,1.073642e-7,0.000005556003,0.000001080104,0.9852838,0.0004278186,0.000944297,0.008477829],"study_design_scores_gemma":[0.0005435098,0.0001802748,0.004992622,0.000005247881,0.0002052804,0.000002230745,0.000005204564,0.0001085293,0.9920489,0.0006199799,0.001173673,0.0001145361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993507,0.0004259879,0.004563493,0.001043517,0.00006004847,0.0002956464,0.00007639427,0.000004897013,0.00002298579],"genre_scores_gemma":[0.9967894,0.0002407142,0.001989521,0.0004235559,0.0001459806,0.0000393841,0.0001938452,0.00001053537,0.0001670836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008363293,"threshold_uncertainty_score":0.2867011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1636684291284207,"score_gpt":0.3612067406418836,"score_spread":0.197538311513463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}