{"id":"W2290513946","doi":"10.1021/acschembio.5b01070","title":"Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Institute of Infection and Immunity; Canada Research Chairs","keywords":"Tobramycin; Aminoglycoside; Resistome; Gentamicin; Antibiotics; Microbiology; Biology; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004927997,0.000301834,0.0005065631,0.0002409609,0.0002282526,0.0006097052,0.0004973647,0.0005842917,0.001185679],"category_scores_gemma":[0.0008455519,0.0002115281,0.000349373,0.0002319227,0.0004475884,0.0006098982,0.0002637807,0.001037628,0.0004083571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005915349,"about_ca_system_score_gemma":0.0006085658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008947781,"about_ca_topic_score_gemma":0.001521337,"domain_scores_codex":[0.9997899,0.00003738814,0.00001239598,0.00002821435,0.0001028386,0.00002925751],"domain_scores_gemma":[0.9997488,0.00008470801,0.00005369068,0.00003183936,0.00004255788,0.00003838223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006969651,0.000153065,0.009681402,0.0004741227,0.00009431786,0.000871012,0.0003156696,0.01166803,0.8766811,0.01373663,0.004008253,0.08161941],"study_design_scores_gemma":[0.0003713081,0.003468962,0.05540911,0.0003544655,0.0003472103,0.01201906,0.001371359,0.1420272,0.4959277,0.03305379,0.2554495,0.000200235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456325,0.015397,0.02222913,0.007832729,0.0001069753,0.00007617574,0.0009794269,0.000514236,0.007231797],"genre_scores_gemma":[0.9700427,0.008096526,0.01798986,0.0008740755,0.0000362486,0.00004243929,0.001668101,0.00008279255,0.001167255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185679,"threshold_uncertainty_score":0.004291892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1636684291284207,"score_gpt":0.3612067406418836,"score_spread":0.197538311513463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}