{"id":"W2290579097","doi":"10.3892/ol.2016.4297","title":"PTEN-mRNA engineered mesenchymal stem cell-mediated cytotoxic effects on U251 glioma cells","year":2016,"lang":"en","type":"article","venue":"Oncology Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Science and Technology Department of Hubei Province","keywords":"PTEN; Tensin; Transfection; Mesenchymal stem cell; Cancer research; Molecular biology; Biology; Chemistry; Cell culture; Cell biology; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269933,0.0004757246,0.0002983635,0.0002146793,0.0001336177,0.0001889803,0.0001465019,0.0002009233,0.0006627934],"category_scores_gemma":[0.00007569398,0.0001031167,0.0002513186,0.0001701684,0.0001817098,0.0001334762,0.0001170256,0.0003862057,0.0001736537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049119,"about_ca_system_score_gemma":0.0002214293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001248472,"about_ca_topic_score_gemma":0.001569025,"domain_scores_codex":[0.9998431,0.00001987514,0.00001684378,0.00002601502,0.00005782796,0.00003635215],"domain_scores_gemma":[0.9999546,0.0000109818,0.00001314071,0.000004883267,0.000007960156,0.000008410039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004667048,0.00002776606,0.00005119662,0.00004732526,0.000003654002,0.00004806158,0.00002249746,0.00007884402,0.9983498,0.0001039586,0.00003162301,0.00118862],"study_design_scores_gemma":[0.000006594653,0.0002129874,0.0005395316,0.000001909511,0.00001276704,0.00004943274,0.00001068522,0.0003722561,0.9978617,0.00001275897,0.0009173845,0.000002074427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905599,0.00170631,0.004244101,0.00009187357,0.00006138483,0.0000722921,0.0002919689,0.0001119425,0.00286025],"genre_scores_gemma":[0.9914272,0.001613986,0.003470494,0.00005607672,0.00001290733,0.00007666679,0.0004390304,0.00001879521,0.002884894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248472,"threshold_uncertainty_score":0.002482414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006323444011771143,"score_gpt":0.2187459791088915,"score_spread":0.2124225350971204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}