{"id":"W2290579097","doi":"10.3892/ol.2016.4297","title":"PTEN-mRNA engineered mesenchymal stem cell-mediated cytotoxic effects on U251 glioma cells","year":2016,"lang":"en","type":"article","venue":"Oncology Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Science and Technology Department of Hubei Province","keywords":"PTEN; Tensin; Transfection; Mesenchymal stem cell; Cancer research; Molecular biology; Biology; Chemistry; Cell culture; Cell biology; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462966,0.0002770651,0.0002696056,0.0001162169,0.0000610912,0.0000137007,0.0003276356,0.0003409747,0.00005076121],"category_scores_gemma":[0.00002522986,0.0002036249,0.000149766,0.00009414356,0.0001032999,0.000006370365,0.00009264123,0.0001360893,0.0006238545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007821607,"about_ca_system_score_gemma":0.00007150037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005709382,"about_ca_topic_score_gemma":0.000006084064,"domain_scores_codex":[0.9984455,0.0001615001,0.0002427165,0.0005174996,0.0001445437,0.0004882342],"domain_scores_gemma":[0.9991118,0.0001531918,0.0001071342,0.0004332007,0.00004582523,0.0001489024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001978583,0.00007860418,0.0001583052,0.00001605994,0.00007293831,0.0001924939,0.0000328537,0.00001395554,0.9492803,0.000003771896,0.04250859,0.00744428],"study_design_scores_gemma":[0.00147023,0.001445948,0.0005427829,0.00003134065,0.00002452604,0.00002629888,0.00001877701,0.000009408307,0.9689106,0.000002818713,0.0272342,0.0002830803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942197,0.0001269669,0.0006415574,0.002610942,0.0009064857,0.000249446,0.00002781855,0.00003843775,0.001178694],"genre_scores_gemma":[0.9933723,0.00009576734,0.0001081469,0.004910905,0.0004835631,0.00005954886,0.00003507975,0.00003595966,0.0008987928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0196303,"threshold_uncertainty_score":0.8303583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006323444011771143,"score_gpt":0.2187459791088915,"score_spread":0.2124225350971204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}