{"id":"W2290683813","doi":"10.1126/scitranslmed.aac6008","title":"Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models","year":2016,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute on Aging; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Burke Foundation; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; National Eye Institute; British Heart Foundation; Wellcome Trust; National Institute of Neurological Disorders and Stroke; Wellcome","keywords":"Rodent model; Pharmacology; Neuroscience; Rodent; Medicine; Chemistry; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005137631,0.0001404907,0.0001942529,0.0001082245,0.00005819601,0.000008747421,0.0001231841,0.00003931609,0.00001288519],"category_scores_gemma":[0.00008309462,0.00008912494,0.0000384893,0.0001131395,0.0004597045,0.00003535798,0.00003200258,0.00005264232,3.619217e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001104943,"about_ca_system_score_gemma":0.0001430231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006483032,"about_ca_topic_score_gemma":0.00008166864,"domain_scores_codex":[0.9986578,0.00003343327,0.0002808998,0.000375341,0.0003988197,0.0002536933],"domain_scores_gemma":[0.9995795,0.00005707207,0.00007043764,0.0001288229,0.00007956774,0.00008452642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001041075,0.00002093318,0.007357809,0.00001665764,0.000008392814,0.000001263783,0.0002514213,0.0001905017,0.9707518,0.0001184389,0.000003792419,0.02117488],"study_design_scores_gemma":[0.006189808,0.000445658,0.6969824,0.0002472426,0.00007002374,0.00007591586,0.0002211645,0.01283868,0.2737183,0.008004566,0.000621489,0.0005847446],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883621,0.003658189,0.00456383,0.002839699,0.000278651,0.0001889661,0.00001556508,0.000006045138,0.00008700433],"genre_scores_gemma":[0.9979782,0.000165184,0.000991152,0.0004744836,0.0002425123,0.000007631071,0.000005687173,0.00000997789,0.0001251472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6970335,"threshold_uncertainty_score":0.363441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369946434871305,"score_gpt":0.2634216827162388,"score_spread":0.2497222183675258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}