{"id":"W2290895720","doi":"10.1371/journal.pone.0149830","title":"EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Hospital for Sick Children; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Canada Research Chairs","keywords":"Serine protease; Coagulation; Tissue factor; Partial thromboplastin time; Lysis; Whole blood; Thromboplastin; Thrombin; Fibrinogen; Microbiology; Chemistry; Biology; Protease; Biochemistry; Molecular biology; Enzyme; Immunology; Internal medicine; Medicine; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693174,0.0004163988,0.0001877845,0.0001973718,0.00005261875,0.0001683833,0.0001266717,0.0002289538,0.000785175],"category_scores_gemma":[0.0002478172,0.00007314057,0.0002302036,0.0001518332,0.0001569771,0.0001342948,0.0001335719,0.0003280797,0.0001760844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001194429,"about_ca_system_score_gemma":0.000111143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518364,"about_ca_topic_score_gemma":0.0001366366,"domain_scores_codex":[0.9998772,0.00003053783,0.00001550631,0.0000185696,0.00003937105,0.00001882636],"domain_scores_gemma":[0.9998963,0.00002680084,0.00003663289,0.000009729835,0.00001382589,0.00001674652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403296,0.00004808834,0.0005187621,0.0000537954,0.0000112845,0.00007517043,0.000003832542,0.000058952,0.9962817,0.00001750695,0.00003935061,0.002651151],"study_design_scores_gemma":[0.00003322627,0.001374732,0.009608153,0.000007638828,0.00002262173,0.000805768,0.00001127438,0.0006006138,0.9865541,0.00002341294,0.0009547816,0.000003564395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933031,0.002051529,0.00365072,0.00007307732,0.00002493621,0.00003153985,0.0002791811,0.00005227619,0.000533534],"genre_scores_gemma":[0.992784,0.001005367,0.004434852,0.00006271676,0.00001493708,0.00002985945,0.001023164,0.000009916753,0.0006352335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000785175,"threshold_uncertainty_score":0.002626657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03875960310070711,"score_gpt":0.2559925954852697,"score_spread":0.2172329923845626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}