{"id":"W2291057641","doi":"10.1071/rd15315","title":"Insulin exposure during in vitro bovine oocyte maturation changes blastocyst gene expression and developmental potential","year":2016,"lang":"en","type":"article","venue":"Reproduction Fertility and Development","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Vetenskapsrådet; Svenska Forskningsrådet Formas","keywords":"Blastocyst; Insulin; Biology; Oocyte; Endocrinology; Internal medicine; In vitro maturation; Downregulation and upregulation; Offspring; Embryo; Hormone; Embryo quality; Andrology; Lipid metabolism; Embryogenesis; Gene; Cell biology; Genetics; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000647396,0.0002105156,0.0002956309,0.0001463634,0.000213326,0.00001468062,0.000038016,0.0001579094,0.00004305563],"category_scores_gemma":[0.0002989642,0.0001467442,0.00002039033,0.0001165151,0.0001605353,0.0001976986,0.0001205028,0.0001459559,0.00001217909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159856,"about_ca_system_score_gemma":0.0001125669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008529018,"about_ca_topic_score_gemma":0.00001209624,"domain_scores_codex":[0.9980087,0.00009810246,0.0004124937,0.001032373,0.0001929349,0.0002554446],"domain_scores_gemma":[0.9993654,0.00001765765,0.00008908176,0.0002985774,0.0001117026,0.0001175048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02786795,0.0001525432,0.01823543,0.000106137,0.00002491315,0.00001204724,0.0008913929,2.961945e-7,0.9036099,2.567523e-7,0.000008037819,0.04909107],"study_design_scores_gemma":[0.0009962257,0.0000490151,0.5168591,0.00004838603,0.000004942603,0.0001003801,0.0001305096,9.42377e-7,0.4813235,0.00001465799,0.0003761641,0.00009612415],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959304,0.00108038,0.0003506788,0.001770968,0.0002225695,0.0005400973,0.000004470634,0.00007194371,0.00002851071],"genre_scores_gemma":[0.9944721,0.0002194432,0.004546841,0.00003819242,0.0001345574,0.00006832604,0.00003086337,0.00001145226,0.0004781897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4986237,"threshold_uncertainty_score":0.5984057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727764198209431,"score_gpt":0.232680084675593,"score_spread":0.2154024426934987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}