{"id":"W2291080332","doi":"10.1113/jp271690","title":"Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism","year":2015,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Office of Science; Medical Research Council; Engineering and Physical Sciences Research Council; Alfred Benzon Foundation; Canadian Institutes of Health Research; Leverhulme Trust","keywords":"Polyamine; Chemistry; Biophysics; Permeation; Ion channel; Kainate receptor; Spermidine; Membrane; Biochemistry; Receptor; AMPA receptor; Biology; Glutamate receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940963,0.000302937,0.0003319989,0.0001563613,0.0001739194,0.0008396563,0.0003590423,0.0003676474,0.001381371],"category_scores_gemma":[0.0001844225,0.0001736633,0.0003540669,0.00008070593,0.0004304703,0.0007067564,0.0004649489,0.000521931,0.0004197825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003514644,"about_ca_system_score_gemma":0.000199039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001609278,"about_ca_topic_score_gemma":0.0003075058,"domain_scores_codex":[0.9997749,0.00001835085,0.00002377288,0.00005163694,0.00007710335,0.00005437713],"domain_scores_gemma":[0.9996852,0.0000475841,0.0001101882,0.00003674137,0.0000450126,0.00007524309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001082625,0.00002115303,0.0002821809,0.00002313323,0.000006020765,0.00003530479,0.00001150771,0.00002768205,0.9985685,0.0001459957,0.00001015379,0.0007601538],"study_design_scores_gemma":[0.0001398905,0.0006662593,0.06030536,0.00001990375,0.00007060316,0.001253354,0.000128239,0.004230005,0.9297833,0.0002718882,0.003116038,0.00001522195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882751,0.002278363,0.006525781,0.0001584448,0.00003958662,0.00003348267,0.00007806811,0.0001077689,0.002503481],"genre_scores_gemma":[0.9953864,0.0006649963,0.001818244,0.00007869168,0.00001877871,0.00002683766,0.0001033409,0.00001523244,0.001887484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381371,"threshold_uncertainty_score":0.004621148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442563240680487,"score_gpt":0.2381600726993859,"score_spread":0.2237344402925811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}