{"id":"W2291151676","doi":"10.1096/fasebj.29.1_supplement.669.4","title":"Re‐investigation into the Ligand Selectivity of OAT2","year":2015,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Nova Scotia Health Research Foundation","keywords":"Chemistry; Organic anion transporter 1; Ligand (biochemistry); In vitro; In vivo; Organic anion; Biochemistry; Transfection; Cell culture; HEK 293 cells; Transporter; Pharmacology; Receptor; Stereochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003607278,0.0003464265,0.0004268466,0.000148862,0.0002343571,0.0008790629,0.0004193336,0.0004126943,0.001270924],"category_scores_gemma":[0.0003375436,0.0001511163,0.0004101569,0.0002118651,0.0002462028,0.0006071427,0.0002519623,0.0009945371,0.0006544018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006441268,"about_ca_system_score_gemma":0.0003435352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001788138,"about_ca_topic_score_gemma":0.001412151,"domain_scores_codex":[0.9996921,0.00004640229,0.00002382215,0.00007442496,0.0001165457,0.00004678246],"domain_scores_gemma":[0.9998395,0.00003401542,0.00001993513,0.00001992205,0.00006837254,0.0000181312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000743616,0.000008736952,0.0005383468,0.0001113225,0.00001008042,0.00008554187,0.00003063043,0.00009002407,0.9958963,0.0002757097,0.0001150966,0.002763831],"study_design_scores_gemma":[0.000007376766,0.0001246031,0.002777801,0.00001710356,0.00003452213,0.0009969131,0.0001168918,0.001672758,0.9714253,0.000103067,0.02271092,0.00001265583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581807,0.02107327,0.01209692,0.001240358,0.000193895,0.00004800001,0.0007537827,0.0001841753,0.006228974],"genre_scores_gemma":[0.9750659,0.009764295,0.005091799,0.0006547983,0.00006971391,0.0000288908,0.001974694,0.0001112066,0.007238624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788138,"threshold_uncertainty_score":0.004673541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02980985124881093,"score_gpt":0.2607772829375463,"score_spread":0.2309674316887353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}