{"id":"W2291152756","doi":"10.1016/s2352-3026(16)00004-1","title":"Pharmacokinetics, safety, and efficacy of subcutaneous versus intravenous rituximab plus chemotherapy as treatment for chronic lymphocytic leukaemia (SAWYER): a phase 1b, open-label, randomised controlled non-inferiority trial","year":2016,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Medicine; Rituximab; Fludarabine; Clinical endpoint; Cyclophosphamide; Pharmacokinetics; Population; Internal medicine; Clinical trial; Surgery; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001915664,0.001378959,0.002926817,0.000307098,0.0003001015,0.00146616,0.0009829098,0.002072778,0.005102742],"category_scores_gemma":[0.002721561,0.0007293379,0.001766274,0.0003718852,0.00170318,0.001607593,0.0004479288,0.004277778,0.001110862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008628569,"about_ca_system_score_gemma":0.0008351595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004824447,"about_ca_topic_score_gemma":0.0007622812,"domain_scores_codex":[0.9990574,0.0005225458,0.000044004,0.0001915242,0.00007223276,0.0001123104],"domain_scores_gemma":[0.9983737,0.0006178992,0.0004361369,0.0001638169,0.00006855592,0.0003397616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9777322,0.004233152,0.0004296238,0.0003412835,0.0006208007,0.00003128031,0.00005503158,0.0002916893,0.00254463,0.0001119236,0.0003610635,0.0132474],"study_design_scores_gemma":[0.92342,0.07394079,0.00102821,0.00002347593,0.0003838779,0.00003195837,0.00002262791,0.0004002589,0.0003109649,0.0001545082,0.0002692339,0.00001421421],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946466,0.002119234,0.0004531313,0.0004572159,0.0002360455,0.0007744368,0.0003150473,0.00006032703,0.0009378553],"genre_scores_gemma":[0.9931108,0.001278928,0.001061326,0.0006968459,0.0002874971,0.001089636,0.0004436098,0.0000265583,0.002004944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005102742,"threshold_uncertainty_score":0.01707041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06490262390275962,"score_gpt":0.4059350666630088,"score_spread":0.3410324427602492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}