{"id":"W2291250082","doi":"10.1371/journal.pone.0144434","title":"Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"G2-M DNA damage checkpoint; CHEK1; DNA damage; Phosphorylation; Cell biology; Cell cycle checkpoint; Chemistry; Checkpoint Kinase 2; Biology; Biophysics; DNA; Cancer research; Biochemistry; Cell cycle; Protein kinase A; Protein-Serine-Threonine Kinases; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408678,0.0004072011,0.0003431806,0.0001818441,0.0002684409,0.0003812726,0.0002857311,0.0003001467,0.002266784],"category_scores_gemma":[0.0001509895,0.0002158276,0.0002249955,0.000123877,0.0002747788,0.0003122358,0.0003089872,0.0005996864,0.0006617404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004755965,"about_ca_system_score_gemma":0.0002451485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004762557,"about_ca_topic_score_gemma":0.0007936451,"domain_scores_codex":[0.9998388,0.00001639749,0.00001092464,0.00004972563,0.00003212488,0.00005185996],"domain_scores_gemma":[0.9998606,0.00002154047,0.00004115831,0.00002246366,0.00001486547,0.00003932822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001549398,0.000009228064,0.0001258396,0.00002021306,0.000002402001,0.00003236099,0.000005239526,0.00003449869,0.9991207,0.00004512976,0.0000190272,0.0004305072],"study_design_scores_gemma":[0.00001014357,0.00006466232,0.005955431,0.000004004652,0.000004426151,0.00009096406,0.00001198716,0.000465148,0.9927821,0.00005598225,0.000551524,0.000003675163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956954,0.001539436,0.001462323,0.00009207858,0.00002971056,0.0000107526,0.000225957,0.0001194416,0.0008249157],"genre_scores_gemma":[0.9978983,0.0002488822,0.0003195296,0.00001554879,0.000004056818,0.00001021506,0.0001590349,0.00001244897,0.001331972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002266784,"threshold_uncertainty_score":0.007583201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03518586013190895,"score_gpt":0.2231491249509671,"score_spread":0.1879632648190581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}