{"id":"W2291261728","doi":"10.1097/pap.0b013e3181c6962f","title":"KRAS Mutation Testing in Human Cancers: The Pathologist's Role in the Era of Personalized Medicine","year":2010,"lang":"en","type":"review","venue":"Advances in Anatomic Pathology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Roche Diagnostics; Amgen","keywords":"KRAS; Panitumumab; Cetuximab; Medicine; Colorectal cancer; Oncology; Internal medicine; Personalized medicine; Companion diagnostic; Clinical trial; Cancer; Bioinformatics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001033272,0.0003421482,0.001793146,0.0002695915,0.00007251684,0.000003984987,0.0003053675,0.0002455408,0.00003065737],"category_scores_gemma":[0.000607794,0.0001717933,0.0001318718,0.0007941187,0.000935796,0.00006191403,0.00005069025,0.00126717,0.000001720913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003867404,"about_ca_system_score_gemma":0.0002890918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032878,"about_ca_topic_score_gemma":0.01007221,"domain_scores_codex":[0.9976441,0.0005027298,0.0008610713,0.0004538489,0.0002057361,0.0003325764],"domain_scores_gemma":[0.9980026,0.001039419,0.0005052657,0.0003727709,0.00005733573,0.00002264875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004407191,0.00008465068,0.004030439,0.001085958,0.0000209408,0.00107908,0.003782067,0.000004783086,0.00001686382,0.0006478946,0.000007256277,0.989196],"study_design_scores_gemma":[0.01047348,0.002901913,0.04058872,0.03376668,0.001596131,0.003853317,0.01395236,0.0001023385,0.000008794575,0.01398684,0.8777627,0.001006686],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01681046,0.9779282,0.000003092877,0.0003179434,0.0002148623,0.001158357,0.00001902997,0.00001212607,0.00353591],"genre_scores_gemma":[0.05195487,0.9468785,0.0001421818,0.0002061842,0.0001092852,0.0006180897,0.00004886543,0.00002172985,0.00002029576],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9881893,"threshold_uncertainty_score":0.7005528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04718882537770906,"score_gpt":0.4067417571767668,"score_spread":0.3595529317990577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}