{"id":"W2291305633","doi":"10.1021/acs.biochem.5b00904","title":"Interaction of the P-Glycoprotein Multidrug Transporter with Sterols","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Cancer Society Research Institute; Canada Research Chairs","keywords":"Sterol; Biochemistry; Phospholipid; Transporter; ATP-binding cassette transporter; Chemistry; Quenching (fluorescence); Cholesterol; Efflux; Binding site; Förster resonance energy transfer; Lipid bilayer; ATPase; Fluorescence; Membrane; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306364,0.0002185282,0.000294191,0.0001342035,0.0002476849,0.0003466343,0.0001525634,0.0003144233,0.0004626825],"category_scores_gemma":[0.0002321466,0.0001140053,0.0002571665,0.0001124832,0.0002220246,0.0003070889,0.0003024424,0.0002919534,0.0002434807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003156406,"about_ca_system_score_gemma":0.0001819064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006597879,"about_ca_topic_score_gemma":0.0006206784,"domain_scores_codex":[0.9998102,0.00006290766,0.00001214143,0.00003887815,0.00004115898,0.00003480966],"domain_scores_gemma":[0.9999359,0.00001996889,0.00001156701,0.000009408996,0.00001329417,0.00000982657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006422394,0.000008252658,0.0005691003,0.00005397373,0.00001319635,0.0001412064,0.0000309286,0.00004560609,0.9976871,0.0002092533,0.00002325771,0.001153865],"study_design_scores_gemma":[0.000007195884,0.0000822745,0.004233475,0.000006557428,0.00001860274,0.0003337384,0.00006181534,0.001002995,0.9918941,0.0001187559,0.002232048,0.000008388493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994093,0.002260619,0.002533731,0.0001465717,0.00001925957,0.00001277894,0.00006086372,0.00001959595,0.0008535481],"genre_scores_gemma":[0.996896,0.001061124,0.001062557,0.00004577713,0.000006538647,0.00001016094,0.00009660348,0.000005431999,0.0008158855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006597879,"threshold_uncertainty_score":0.00229013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161981869676076,"score_gpt":0.2375521748044339,"score_spread":0.2213539878368263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}