{"id":"W2291305633","doi":"10.1021/acs.biochem.5b00904","title":"Interaction of the P-Glycoprotein Multidrug Transporter with Sterols","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Cancer Society Research Institute; Canada Research Chairs","keywords":"Sterol; Biochemistry; Phospholipid; Transporter; ATP-binding cassette transporter; Chemistry; Quenching (fluorescence); Cholesterol; Efflux; Binding site; Förster resonance energy transfer; Lipid bilayer; ATPase; Fluorescence; Membrane; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006442079,0.00008937249,0.0001347442,0.00001088009,0.00001542446,0.000003097874,0.00007191777,0.00006360876,0.00003493743],"category_scores_gemma":[0.000005362304,0.0000490449,0.00006388933,0.00007533739,0.0000615791,0.00002517259,0.000004492182,0.0001110948,0.000002965975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000028568,"about_ca_system_score_gemma":0.00009530646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001588245,"about_ca_topic_score_gemma":0.000008986134,"domain_scores_codex":[0.9994037,0.000004787138,0.0001414286,0.0001297024,0.0002237607,0.00009664409],"domain_scores_gemma":[0.99951,0.000003293198,0.00006799208,0.0002657849,0.00007404268,0.00007883568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001063696,0.0001911828,0.01371511,0.0003010608,0.00006275347,0.00002794349,0.0004966226,0.000005513344,0.9827499,0.00001066983,0.0004501874,0.000925315],"study_design_scores_gemma":[0.001313702,0.00005998113,0.004628173,0.0002847313,0.00006222668,0.00003245232,0.0005001946,0.0000179238,0.9915388,0.00001171877,0.001484113,0.00006596601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959986,0.00006859214,0.0002789246,0.0004219249,0.000113304,0.0001896714,0.000006501033,0.00002241503,0.002900111],"genre_scores_gemma":[0.9950945,0.000002109842,0.0006240956,0.00006825526,0.00006280171,0.00001204385,0.00001556065,0.00001202103,0.004108645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00908694,"threshold_uncertainty_score":0.1999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161981869676076,"score_gpt":0.2375521748044339,"score_spread":0.2213539878368263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}