{"id":"W2291349339","doi":"10.1101/mcs.a000679","title":"Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing","year":2016,"lang":"en","type":"article","venue":"Molecular Case Studies","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre","funders":"Terry Fox Foundation; Michael Smith Health Research BC","keywords":"Chronic lymphocytic leukemia; Genome; Lymphoproliferative disorders; Biology; DNA sequencing; Transcriptome; Lymphoma; Gene expression profiling; Whole genome sequencing; Gene; Digital polymerase chain reaction; Genetics; Cancer genome sequencing; Leukemia; Computational biology; Gene expression; Polymerase chain reaction; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003394951,0.0003179463,0.0007027492,0.0001738155,0.0001048362,0.000009211986,0.0001418625,0.0001391686,0.00002670917],"category_scores_gemma":[0.0006358988,0.0002129171,0.0001623216,0.0002386206,0.0006303395,0.00008547659,0.0002571204,0.0001198822,0.00002331945],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004348799,"about_ca_system_score_gemma":0.001488993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001962921,"about_ca_topic_score_gemma":0.00004380056,"domain_scores_codex":[0.9976466,0.0002689958,0.0004844273,0.0005818469,0.0004575663,0.0005605211],"domain_scores_gemma":[0.9983898,0.000152856,0.0001360535,0.0006682985,0.0004391038,0.0002138302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002894578,0.0001263537,0.0001324882,0.0002097571,0.0007276828,0.03284049,0.001540909,0.00003893157,0.9598998,0.0001135837,0.00007432049,0.004006218],"study_design_scores_gemma":[0.03459704,0.003160391,0.00007446132,0.0004807285,0.0004968218,0.02485404,0.004019966,0.001337608,0.9279578,0.0004399012,0.001811287,0.0007699777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899223,0.005581089,0.002724118,0.0006905959,0.00005706066,0.0006688386,0.00009039508,0.00005135553,0.0002142663],"genre_scores_gemma":[0.9982856,0.0002268214,0.0005464017,0.0004369224,0.00004057494,0.0001430034,0.00003193839,0.0000547967,0.0002339499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03430758,"threshold_uncertainty_score":0.9994733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502612341013688,"score_gpt":0.3293395031984806,"score_spread":0.3043133797883437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}