{"id":"W2291416078","doi":"10.1155/2016/6234043","title":"Bach1 Induces Endothelial Cell Apoptosis and Cell‐Cycle Arrest through ROS Generation","year":2016,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Public Health Service; Fudan University; National Natural Science Foundation of China","keywords":"Cell biology; Apoptosis; Cyclin D1; Cell cycle; Reactive oxygen species; Downregulation and upregulation; Cell cycle checkpoint; Cell growth; Mitochondrial ROS; Biology; Cyclin A; Oxidative stress; Cyclin E; Mitochondrion; Endothelial stem cell; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248359,0.0002055629,0.0002012541,0.00003292051,0.0001541675,0.00001702726,0.0000707974,0.0001565508,0.00008396965],"category_scores_gemma":[0.00003492022,0.0001303489,0.00003912654,0.0000544089,0.0002097291,0.00001894019,0.00008248787,0.00006617913,0.000005985319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001017414,"about_ca_system_score_gemma":0.00002129111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006332868,"about_ca_topic_score_gemma":0.00001565556,"domain_scores_codex":[0.998893,0.0001036805,0.0001971238,0.0004540548,0.000153812,0.0001983932],"domain_scores_gemma":[0.9994712,0.00002487847,0.0001155753,0.0002249869,0.00006105687,0.0001022686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002675253,0.0000438919,0.0002076907,0.00002658276,0.00001492839,0.000001621625,0.0002479144,9.720455e-7,0.9876763,0.0001333943,0.0004319418,0.01118797],"study_design_scores_gemma":[0.001165882,0.0003810767,0.0003157016,0.00002764742,0.00004986552,0.000002748717,0.0001522207,0.00003887394,0.9862845,0.0002250212,0.01116362,0.0001928488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711924,0.002649181,0.02348369,0.0004947761,0.0002500149,0.0002198798,0.00001867572,0.00001033524,0.001681067],"genre_scores_gemma":[0.9937646,0.003157755,0.0005185661,0.0001612007,0.000848727,0.00001582469,0.0001128658,0.00001985673,0.001400538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02296513,"threshold_uncertainty_score":0.5315473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942090766685139,"score_gpt":0.2410178467869598,"score_spread":0.2215969391201084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}