{"id":"W2291416078","doi":"10.1155/2016/6234043","title":"Bach1 Induces Endothelial Cell Apoptosis and Cell‐Cycle Arrest through ROS Generation","year":2016,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Public Health Service; Fudan University; National Natural Science Foundation of China","keywords":"Cell biology; Apoptosis; Cyclin D1; Cell cycle; Reactive oxygen species; Downregulation and upregulation; Cell cycle checkpoint; Cell growth; Mitochondrial ROS; Biology; Cyclin A; Oxidative stress; Cyclin E; Mitochondrion; Endothelial stem cell; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749092,0.000231888,0.0002042436,0.0001994574,0.0001531908,0.0002125719,0.00009103987,0.0001194908,0.0008752663],"category_scores_gemma":[0.000126203,0.0000792811,0.0001665811,0.0001211724,0.0001803464,0.0001870333,0.0001853139,0.0003577131,0.0001520844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002278509,"about_ca_system_score_gemma":0.000187717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000389148,"about_ca_topic_score_gemma":0.000431187,"domain_scores_codex":[0.9999106,0.00002115546,0.000007511689,0.00001243196,0.00001768967,0.00003062033],"domain_scores_gemma":[0.9999446,0.00000722695,0.00001828625,0.000005826372,0.000008227322,0.00001592013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001378115,0.00002447989,0.0003405038,0.00004485697,0.000006967539,0.00004513125,0.00001399258,0.00005457035,0.9966717,0.0002207803,0.000065097,0.00237405],"study_design_scores_gemma":[0.00004656478,0.0004994974,0.008177746,0.000006924321,0.00001731216,0.0003068892,0.00002670438,0.0008821469,0.9873686,0.0001613567,0.002501229,0.000004945781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895136,0.005687885,0.00277015,0.0001402035,0.00003576398,0.00002753614,0.0001652674,0.00006297461,0.001596586],"genre_scores_gemma":[0.9967813,0.001377217,0.0006198251,0.00003592157,0.00001250297,0.00001449165,0.0001665024,0.000003319139,0.0009889266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008752663,"threshold_uncertainty_score":0.002928078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942090766685139,"score_gpt":0.2410178467869598,"score_spread":0.2215969391201084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}