{"id":"W2291450044","doi":"10.1074/jbc.m116.718973","title":"Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Argonne National Laboratory; National Natural Science Foundation of China; Wellcome Trust; Biological and Environmental Research; University of Chicago","keywords":"Histone H3; Histone; Histone H1; Histone code; Histone octamer; Histone H2A; Histone methyltransferase; Biochemistry; Biology; Nucleosome; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102405,0.0001223782,0.0002852937,0.00003394208,0.00003336901,0.000003928787,0.0001637807,0.0002649698,0.00004982883],"category_scores_gemma":[0.0001882759,0.00008079928,0.0001665835,0.00006638277,0.0001960277,0.000007928305,0.00005599924,0.00008672178,3.678712e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006917143,"about_ca_system_score_gemma":0.00007700788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002002237,"about_ca_topic_score_gemma":3.472815e-7,"domain_scores_codex":[0.9988836,0.00004267702,0.0006315378,0.00015691,0.0001437102,0.0001415874],"domain_scores_gemma":[0.9986656,0.00002902224,0.0008753527,0.0001642949,0.0002094553,0.00005631829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002336655,0.00005258568,0.006359768,0.00004640746,0.0000532563,0.000001265026,0.00003011466,0.000002889592,0.9921473,0.000009307196,0.00001898465,0.001044408],"study_design_scores_gemma":[0.0006308068,0.0005614819,0.01913216,0.0001497794,0.00001383739,0.0000212546,0.00008572914,5.637499e-7,0.9785471,0.0001203857,0.0006337287,0.0001031939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982488,0.0002493835,0.001044866,0.00008671893,0.00006357842,0.00008262425,0.00002551517,0.000003985645,0.0001945608],"genre_scores_gemma":[0.9990867,0.0001328827,0.0002905001,0.000011236,0.0002537449,0.0000036343,0.00003724873,0.000009592086,0.0001744984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01360027,"threshold_uncertainty_score":0.3294899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582924668990094,"score_gpt":0.2690664912511759,"score_spread":0.2532372445612749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}