{"id":"W2291492841","doi":"10.1038/srep22460","title":"Regulation of global gene expression and cell proliferation by APP","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Cell growth; Neurogenesis; Downregulation and upregulation; Cell cycle; Biology; Amyloid precursor protein; Cell biology; Cell; Gene expression; Gene expression profiling; Cancer research; Alzheimer's disease; Gene; Genetics; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006412093,0.0002860822,0.0001907999,0.0003006439,0.0001297476,0.0003046612,0.00006828422,0.0001298897,0.0005414008],"category_scores_gemma":[0.00008232403,0.00009779342,0.0001895281,0.0002212617,0.0001836847,0.0001779468,0.0001359483,0.0001883729,0.000144799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629953,"about_ca_system_score_gemma":0.0001269625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005191321,"about_ca_topic_score_gemma":0.0007337851,"domain_scores_codex":[0.9999026,0.00001112288,0.000006535179,0.00003356169,0.00002385803,0.00002227401],"domain_scores_gemma":[0.999963,0.000007695003,0.00001068035,0.000004620268,0.000006416938,0.000007516806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006280247,0.000008158636,0.0009026104,0.00002253796,0.000005812882,0.00003287279,0.00001624189,0.00003520673,0.9970376,0.00004615698,0.0000213048,0.001808684],"study_design_scores_gemma":[0.0000105348,0.0003318021,0.1310429,0.00001204416,0.00004973812,0.0003949947,0.0000959461,0.0009656245,0.8639158,0.0002055655,0.002965633,0.000009347745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919456,0.004019535,0.001916829,0.00003595532,0.00001709859,0.00001519281,0.0005558716,0.00003407696,0.00145976],"genre_scores_gemma":[0.9930502,0.002847403,0.001653676,0.00003977376,0.0000113802,0.00004772301,0.0007869008,0.00000847363,0.001554474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005414008,"threshold_uncertainty_score":0.001811147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397526481896559,"score_gpt":0.2826925463103396,"score_spread":0.268717281491374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}