{"id":"W2291628201","doi":"10.1093/neuonc/nov125","title":"Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions","year":2015,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Western Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Warburg effect; Reprogramming; Oxidative phosphorylation; Citric acid cycle; Biology; Anaerobic glycolysis; Glycolysis; Epigenetics; Metabolism; Metabolic pathway; Cancer research; Cell biology; Biochemistry; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005035719,0.0005437378,0.000983828,0.001546639,0.0003064028,0.000909802,0.0005500661,0.001066317,0.00245354],"category_scores_gemma":[0.000656097,0.0001826442,0.0003482817,0.001505222,0.000574032,0.001452684,0.000740185,0.001369586,0.001069791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008277686,"about_ca_system_score_gemma":0.001021472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008891899,"about_ca_topic_score_gemma":0.00184007,"domain_scores_codex":[0.9998846,0.00002300061,0.0000180097,0.0000239861,0.00003510196,0.00001533737],"domain_scores_gemma":[0.9997286,0.0001208341,0.00003724919,0.00001044193,0.0000694379,0.00003326644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005323404,0.00003404753,0.000308734,0.01002344,0.00007209252,0.0003382839,0.00009497038,0.0004023311,0.002398103,0.009065205,0.02922395,0.9479856],"study_design_scores_gemma":[0.000006160741,0.00005375136,0.0009804071,0.002387555,0.00007585581,0.001859553,0.0000879037,0.0001096328,0.0007206412,0.005782438,0.9879153,0.00002082477],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001211164,0.9983956,0.0001316827,0.0005277662,0.0001760928,0.000001495726,0.00001447998,0.000007380816,0.0006243602],"genre_scores_gemma":[0.0009124654,0.9981495,0.000120753,0.0002406082,0.0001760816,0.000002569028,0.00001941357,0.00000132888,0.0003773246],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00245354,"threshold_uncertainty_score":0.008207917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686097690080706,"score_gpt":0.3492630397369131,"score_spread":0.3224020628361061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}