{"id":"W2291703036","doi":"10.1139/cjc-2015-0598","title":"Galactose-amidine derivatives as selective antagonists of galectin-9","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lunds Universitet","keywords":"Chemistry; Amidine; Sulfonyl; Galectin; Hydrogen bond; Combinatorial chemistry; Stereochemistry; Glycosylation; Selectivity; Molecule; Organic chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012553,0.0003099432,0.0002403752,0.0001122267,0.00008691637,0.0001594031,0.0002690238,0.0002469775,0.0009955752],"category_scores_gemma":[0.0001152099,0.0001138696,0.0002075436,0.0001139782,0.0001287207,0.0001845073,0.000203425,0.0004360174,0.0002796113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221123,"about_ca_system_score_gemma":0.0001221061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004102181,"about_ca_topic_score_gemma":0.001150711,"domain_scores_codex":[0.9999115,0.00002465404,0.000003971045,0.00001397313,0.00002478114,0.00002105087],"domain_scores_gemma":[0.9999604,0.000008662105,0.00001157882,0.000003688039,0.000005594227,0.00001003898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002173054,0.00005836621,0.000130649,0.00005775845,0.0000154501,0.00006191745,0.00001221188,0.0006050905,0.9943752,0.0002546807,0.00009331921,0.004118189],"study_design_scores_gemma":[0.00009363009,0.001465437,0.0009914112,0.000006921289,0.00002894611,0.0002604286,0.00001161142,0.002443224,0.9902164,0.00006180561,0.004408657,0.00001161508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883134,0.003160382,0.004380182,0.0001040948,0.00004189574,0.0001054388,0.0001753026,0.00007149741,0.003647662],"genre_scores_gemma":[0.9912605,0.002014182,0.004135671,0.0000899287,0.00001208623,0.00004749301,0.0002094925,0.00001314579,0.002217614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009955752,"threshold_uncertainty_score":0.003330529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006768318937036629,"score_gpt":0.2152435520651452,"score_spread":0.2084752331281085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}