{"id":"W2291768935","doi":"10.1155/2016/9570424","title":"Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control","year":2016,"lang":"en","type":"article","venue":"Journal of Diabetes Research","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; National Institutes of Health; Faculty of Health and Medical Sciences, University of Western Australia; European Foundation for the Study of Diabetes; Universität Ulm; Hospital for Sick Children; University of Dundee; Danmarks Frie Forskningsfond; Kitasato University; Juvenile Diabetes Research Foundation United Kingdom; Novo Nordisk; Herlev Hospital; Università degli Studi di Parma; Savvaerksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat","keywords":"Glycemic; Islet; Disease; Gene; Diabetes mellitus; Medicine; Type 2 diabetes; Candidate gene; Type 1 diabetes; Oncology; Internal medicine; Bioinformatics; Genetics; Biology; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007689605,0.000227188,0.0004149582,0.0002614458,0.00009074037,0.00004489435,0.0003238776,0.0001882811,0.00001132597],"category_scores_gemma":[0.001087642,0.0001600037,0.0001378267,0.0002492111,0.0002145084,0.00002442731,0.0001161953,0.0001679348,6.59996e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000635703,"about_ca_system_score_gemma":0.0006296243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003678368,"about_ca_topic_score_gemma":0.00001558815,"domain_scores_codex":[0.9973533,0.0003382305,0.000659714,0.0003557786,0.0006027502,0.0006902017],"domain_scores_gemma":[0.9974692,0.000257737,0.0004590156,0.0002844675,0.001149202,0.0003803522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001303497,0.0002162982,0.7610339,0.00009128624,0.0001772513,0.000001262138,0.00002227207,0.0008612096,0.2237125,3.750433e-7,0.0007361124,0.01184399],"study_design_scores_gemma":[0.02824656,0.006601727,0.7741424,0.001841644,0.0003316051,5.758201e-7,0.00004613056,0.02040131,0.164733,0.001572399,0.001405489,0.0006771281],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892594,0.009268778,0.0001962496,0.0001637597,0.00007232072,0.0006378978,0.0003934626,0.000004412911,0.000003704658],"genre_scores_gemma":[0.9970016,0.002174709,0.000508407,0.00004100249,0.000139424,0.00002705506,0.00004101596,0.00004543772,0.0000213792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05897952,"threshold_uncertainty_score":0.652476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103919752021985,"score_gpt":0.2675055642690316,"score_spread":0.2564663667488117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}