{"id":"W2291768935","doi":"10.1155/2016/9570424","title":"Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control","year":2016,"lang":"en","type":"article","venue":"Journal of Diabetes Research","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; National Institutes of Health; Faculty of Health and Medical Sciences, University of Western Australia; European Foundation for the Study of Diabetes; Universität Ulm; Hospital for Sick Children; University of Dundee; Danmarks Frie Forskningsfond; Kitasato University; Juvenile Diabetes Research Foundation United Kingdom; Novo Nordisk; Herlev Hospital; Università degli Studi di Parma; Savvaerksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat","keywords":"Glycemic; Islet; Disease; Gene; Diabetes mellitus; Medicine; Type 2 diabetes; Candidate gene; Type 1 diabetes; Oncology; Internal medicine; Bioinformatics; Genetics; Biology; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002595474,0.001044726,0.0009038028,0.001803973,0.0004260084,0.001216892,0.0006800253,0.0007928537,0.00194293],"category_scores_gemma":[0.006236384,0.0002242621,0.001697373,0.001152623,0.0003383068,0.0003269085,0.0007220904,0.0008164409,0.0003047818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004718346,"about_ca_system_score_gemma":0.0007975728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01283951,"about_ca_topic_score_gemma":0.006103657,"domain_scores_codex":[0.9990582,0.0004968196,0.00005313766,0.0002141035,0.00009254159,0.00008524054],"domain_scores_gemma":[0.9963791,0.002444839,0.0005132009,0.0001952725,0.0001899775,0.0002776501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001301658,0.000227032,0.8024806,0.00004760088,0.0009999797,0.00045147,0.000144858,0.1692827,0.001715957,0.0008615105,0.0006681432,0.02181845],"study_design_scores_gemma":[0.00008026809,0.0002452585,0.09901156,0.00002089165,0.0002894515,0.0002806231,0.00007637971,0.8971898,0.000335866,0.002123828,0.0003177215,0.00002839189],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689115,0.0003055435,0.02898737,0.0002732803,0.00002529616,0.00004815222,0.0007833495,0.0002184635,0.0004469859],"genre_scores_gemma":[0.992528,0.00007531465,0.006282284,0.00002620651,0.00001332429,0.00002941751,0.0007396617,0.00001857396,0.0002871969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01283951,"threshold_uncertainty_score":0.02552956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103919752021985,"score_gpt":0.2675055642690316,"score_spread":0.2564663667488117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}