{"id":"W2291922972","doi":"10.1002/chem.201600847","title":"Catalytic Asymmetric Prins Bicyclization for the <i>endo</i>‐Selective Formation of 2,6‐dioxabicyclo[2.2.2]octanes","year":2016,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fudan University; National Natural Science Foundation of China; Ryerson University","keywords":"Catalysis; Chemistry; Glyoxylate cycle; Bicyclic molecule; Organic chemistry; Prins reaction; Stereochemistry; Combinatorial chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00130738,0.0003125503,0.0003149423,0.0000536562,0.0002893636,0.00007700946,0.0008091794,0.00009093212,0.0003577938],"category_scores_gemma":[0.00337195,0.0001957077,0.0002793244,0.0003725727,0.0002048761,0.0002144594,0.0001222251,0.0003111991,0.00002020649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787958,"about_ca_system_score_gemma":0.0001421299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001032435,"about_ca_topic_score_gemma":1.945957e-7,"domain_scores_codex":[0.997858,0.00009749286,0.0008521577,0.00033655,0.0004193111,0.0004365066],"domain_scores_gemma":[0.9968174,0.001078578,0.0008981713,0.0006245264,0.0003966385,0.0001847294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008567631,0.00007029455,0.0001395885,0.0002686315,0.00008893957,0.00001048684,0.0001880516,0.000009169885,0.9185845,0.000008638482,0.001076146,0.07946989],"study_design_scores_gemma":[0.001545527,0.00002209666,0.0001382022,0.0002420059,0.0001574682,0.001118163,0.0002614229,0.0004000156,0.9803923,0.0001651243,0.01529307,0.00026455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5660358,0.001830318,0.2951324,0.002704116,0.0006598075,0.0005543414,0.0003266728,0.0003523743,0.1324042],"genre_scores_gemma":[0.9939765,0.0002370674,0.001756738,0.00002693413,0.0009495182,0.00001371573,0.0000159108,0.00009498314,0.002928662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4279407,"threshold_uncertainty_score":0.7980728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064851747356483,"score_gpt":0.2530874100971146,"score_spread":0.2324388926235497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}