{"id":"W2292274773","doi":"10.1002/gepi.21940","title":"Causal Genetic Inference Using Haplotypes as Instrumental Variables","year":2015,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; National Institute of General Medical Sciences; GlaxoSmithKline","keywords":"Single-nucleotide polymorphism; Haplotype; Causal inference; Inference; Biology; Instrumental variable; Genetic association; Genetics; Computational biology; Genotype; Gene; Statistics; Computer science; Mathematics; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01143315,0.0008614229,0.001597311,0.001600381,0.0004087713,0.001014703,0.001532203,0.001132387,0.003189351],"category_scores_gemma":[0.04047934,0.0007679767,0.00178548,0.00160587,0.001328799,0.001610957,0.001938856,0.002207544,0.0004050402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005408999,"about_ca_system_score_gemma":0.001698038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0028919,"about_ca_topic_score_gemma":0.002678162,"domain_scores_codex":[0.993895,0.004630118,0.0001707403,0.0007634393,0.0003340604,0.0002065757],"domain_scores_gemma":[0.967876,0.02836945,0.001317341,0.00166519,0.0005393401,0.000232867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005045794,0.0002247972,0.04128216,0.000475329,0.001304261,0.0009285961,0.0004233415,0.4937062,0.003140301,0.2425679,0.001544495,0.2138981],"study_design_scores_gemma":[0.0001155185,0.000126304,0.002821821,0.00004856639,0.0001508356,0.0001454453,0.000040832,0.8375787,0.00113795,0.1562463,0.00154568,0.00004200786],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.007063915,0.0001216289,0.992301,0.00008755571,0.00001955214,0.00003168367,0.00007109131,0.00009300332,0.0002106223],"genre_scores_gemma":[0.4385008,0.0008223277,0.5561372,0.0003789332,0.0001970549,0.0004035346,0.0005744574,0.0001256743,0.002859959],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01143315,"threshold_uncertainty_score":0.06046504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07050635572516877,"score_gpt":0.344059698794827,"score_spread":0.2735533430696582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}