{"id":"W2292299498","doi":"10.1186/s12879-016-1444-z","title":"A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis","year":2016,"lang":"en","type":"article","venue":"BMC Infectious Diseases","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; McGill University Health Centre; Public Health Agency; Public Health Agency of Canada; McGill University","keywords":"Schistosoma mansoni; Immunology; Adjuvant; Schistosomiasis; Antigen; Cathepsin B; Schistosoma; Biology; Antibody; Antibody titer; Medicine; Virology; Titer; Helminths","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002037509,0.0005146668,0.0003206811,0.0003361269,0.00009323879,0.0002078805,0.0001925505,0.0005736409,0.0009982269],"category_scores_gemma":[0.0001682727,0.0001812848,0.0002482228,0.0001115603,0.0002389084,0.000231425,0.0001435578,0.0008766059,0.0002535194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967379,"about_ca_system_score_gemma":0.0001790843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002702222,"about_ca_topic_score_gemma":0.0003956195,"domain_scores_codex":[0.9998688,0.0000191927,0.00001129475,0.00002632041,0.00003185918,0.00004262783],"domain_scores_gemma":[0.9998486,0.00002583657,0.00004595319,0.00001243313,0.0000174706,0.00004961329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005092266,0.000357712,0.000143309,0.00005586514,0.000008616581,0.00002584557,0.00001126159,0.0001178217,0.9971614,0.00004119103,0.00004839915,0.001519456],"study_design_scores_gemma":[0.0003301543,0.01378606,0.005546039,0.00002886084,0.0000558116,0.0002252215,0.00002851236,0.001513403,0.9767222,0.00005373931,0.001702349,0.000007599477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997328,0.000520414,0.0009857118,0.00008805349,0.00004670977,0.00004820352,0.0001187275,0.00008396036,0.0007800543],"genre_scores_gemma":[0.9960355,0.0004452259,0.001367759,0.00007566317,0.00002621876,0.00005106295,0.0004848783,0.00001344155,0.001500207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009982269,"threshold_uncertainty_score":0.00333941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476359949010975,"score_gpt":0.2546453051362568,"score_spread":0.2298817056461471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}