{"id":"W2292390406","doi":"10.1182/blood.v122.21.4071.4071","title":"Baseline Characteristics and Symptom Burden in RESPONSE: A Randomized, Open-Label, Phase 3 Study of Ruxolitinib In Polycythemia Vera Patients Resistant to or Intolerant of Hydroxyurea","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Phlebotomy; Medicine; Ruxolitinib; Polycythemia vera; Internal medicine; Hematocrit; Phases of clinical research; Myelofibrosis; Myeloproliferative neoplasm; Clinical trial; Gastroenterology; Surgery; Bone marrow","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001802009,0.0009590901,0.001731673,0.0003599428,0.0005377185,0.0009403044,0.0005992925,0.001178846,0.003527645],"category_scores_gemma":[0.001140813,0.0004236862,0.001546749,0.000403682,0.000704594,0.0008661171,0.000331631,0.00260305,0.0004428905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006431466,"about_ca_system_score_gemma":0.0008778065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000652205,"about_ca_topic_score_gemma":0.001255058,"domain_scores_codex":[0.9991843,0.0004558939,0.00004888199,0.0001180549,0.00006878251,0.0001242161],"domain_scores_gemma":[0.9988971,0.0002120115,0.0002639628,0.00005291953,0.00007093027,0.0005030225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8896373,0.04361231,0.01883354,0.0005230638,0.001520668,0.0002377511,0.0001618617,0.001099554,0.0162862,0.00008515783,0.001702537,0.02629996],"study_design_scores_gemma":[0.6597106,0.2893488,0.04536095,0.00002883447,0.0007991939,0.0002802896,0.00007641632,0.001503665,0.001624463,0.0001343551,0.001094909,0.00003759609],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962425,0.0008749631,0.0002099108,0.0001820812,0.0000543837,0.001257495,0.0006297785,0.00003394454,0.0005149198],"genre_scores_gemma":[0.9962648,0.000298401,0.0003841713,0.0004088854,0.0001154633,0.001242273,0.0008033266,0.000006655234,0.0004761241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003527645,"threshold_uncertainty_score":0.01180112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258339436463784,"score_gpt":0.3188945622463815,"score_spread":0.2963111678817436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}