{"id":"W2292465039","doi":"10.1111/hae.12905","title":"Association of peak factor <scp>VIII</scp> levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic‐guided prophylaxis","year":2016,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Baxalta","keywords":"Medicine; Haemophilia; Pharmacokinetics; Dosing; Haemophilia A; Area under the curve; Trough level; Internal medicine; Post-hoc analysis; Gastroenterology; Surgery; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005168454,0.0002293717,0.0004628131,0.0003924884,0.0002325575,0.0005611032,0.0001706273,0.000362044,0.001325472],"category_scores_gemma":[0.002548619,0.0001473973,0.0003479553,0.0004831267,0.0002381039,0.0002317531,0.0001624079,0.0006458813,0.0001714378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002633312,"about_ca_system_score_gemma":0.000274229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007444723,"about_ca_topic_score_gemma":0.0004115761,"domain_scores_codex":[0.9996403,0.0000906304,0.00003342855,0.00008347209,0.0000908017,0.00006119227],"domain_scores_gemma":[0.9974226,0.0009390246,0.0009559739,0.0001222606,0.0001420443,0.0004180601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009571632,0.00005473554,0.9946562,0.000008737338,0.00006603783,0.0001333155,0.00002562224,0.0001620073,0.0007738455,0.00001209663,0.00008873516,0.003061582],"study_design_scores_gemma":[0.00003104855,0.001215992,0.9966285,0.000003392692,0.00004753425,0.0009964454,0.00002988553,0.0006430915,0.0002522935,0.00002445349,0.0001220664,0.000005249356],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995012,0.0001950143,0.0000812911,0.00001996179,0.000002088974,0.000003277459,0.00005461453,0.000004078031,0.0001383282],"genre_scores_gemma":[0.9997669,0.00004547591,0.0000581628,0.000006338473,0.000005788013,0.000002446255,0.00008185508,0.000001411863,0.00003156324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325472,"threshold_uncertainty_score":0.004434109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03406999344388351,"score_gpt":0.2789250472880203,"score_spread":0.2448550538441368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}