{"id":"W2292616952","doi":"10.1016/j.chembiol.2015.12.005","title":"The Intersection of Structural and Chemical Biology - An Essential Synergy","year":2016,"lang":"en","type":"review","venue":"Cell chemical biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Wellcome; Janssen Biotech; Innovative Medicines Initiative; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; AbbVie; Merck; Pfizer; Boehringer Ingelheim","keywords":"Chemical biology; Intersection (aeronautics); Computational biology; Structural biology; Rational design; Biology; Computer science; Biochemical engineering; Engineering; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001361583,0.001136361,0.002108912,0.00163088,0.0003981172,0.002584636,0.001562739,0.002315134,0.002197817],"category_scores_gemma":[0.0009747666,0.000461164,0.0004148457,0.002150914,0.002082298,0.004788707,0.001599301,0.00469973,0.001619657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00136255,"about_ca_system_score_gemma":0.001676084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006855829,"about_ca_topic_score_gemma":0.001820275,"domain_scores_codex":[0.9996259,0.00006855594,0.00004198838,0.00005874121,0.0001566189,0.00004825952],"domain_scores_gemma":[0.9994385,0.0003109035,0.00005069449,0.00002743673,0.0001167399,0.00005572912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001684966,0.0001162858,0.0001720868,0.01422455,0.0001001981,0.0003796776,0.0001495936,0.0007682198,0.006156232,0.05958739,0.06153576,0.8566415],"study_design_scores_gemma":[0.00001452447,0.00005028121,0.0001665729,0.00156521,0.0000341296,0.0006914003,0.00006556417,0.0001156107,0.0008263717,0.01316447,0.9832875,0.00001853456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007602228,0.9971018,0.000374402,0.0009091038,0.0003711134,0.000002178188,0.000006939068,0.000008615195,0.001149741],"genre_scores_gemma":[0.0008683035,0.9967386,0.0004100185,0.0007799364,0.0004217722,0.000005493234,0.00001447483,0.000002962457,0.0007584175],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002584636,"threshold_uncertainty_score":0.009886026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025799277519672,"score_gpt":0.2839786958213261,"score_spread":0.2737207030461293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}