{"id":"W2292654267","doi":"10.3233/jad-150978","title":"Efficacy and Safety of ABT-126 in Subjects with Mild-to-Moderate Alzheimer’s Disease on Stable Doses of Acetylcholinesterase Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Study","year":2016,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"AbbVie","keywords":"Acetylcholinesterase; Placebo; Medicine; Randomized controlled trial; Acetylcholinesterase inhibitor; Double blind; Disease; Galantamine; Alzheimer's disease; Pharmacology; Internal medicine; Dementia; Donepezil; Alternative medicine; Pathology; Enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001510283,0.0005068399,0.001619575,0.0003926361,0.0000682637,0.00003552566,0.0003456667,0.00009164008,0.00002226043],"category_scores_gemma":[0.0006250662,0.0003029077,0.0003990445,0.000283626,0.00024241,0.00004901655,0.0001883936,0.0002114683,0.000002827665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002518544,"about_ca_system_score_gemma":0.0006236844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000291358,"about_ca_topic_score_gemma":0.00003381128,"domain_scores_codex":[0.9959921,0.000660853,0.001688681,0.0005613032,0.0006691095,0.0004279768],"domain_scores_gemma":[0.9964417,0.0003583862,0.001206261,0.0006304619,0.0005316107,0.0008315655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9712176,0.003783449,0.0121852,0.00002778203,0.002990747,0.00003143371,0.0002537491,0.0007449174,0.007984852,0.00001032227,0.0001992926,0.0005706148],"study_design_scores_gemma":[0.9345228,0.001995679,0.004360873,0.0006684516,0.004499034,0.00001065087,0.0002167131,0.00002269431,0.05311339,0.00001099061,0.00008683834,0.0004918588],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874739,0.007683399,0.00008507415,0.0005296694,0.0001628612,0.003957876,0.00006501849,0.000007067124,0.00003513264],"genre_scores_gemma":[0.9986509,0.0005272559,0.0001864628,0.0001141444,0.0002810891,0.0001334417,0.00001011083,0.00006462057,0.00003199428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04512854,"threshold_uncertainty_score":0.9999423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341966113121187,"score_gpt":0.2993117284915029,"score_spread":0.275892067360291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}