{"id":"W2292654267","doi":"10.3233/jad-150978","title":"Efficacy and Safety of ABT-126 in Subjects with Mild-to-Moderate Alzheimer’s Disease on Stable Doses of Acetylcholinesterase Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Study","year":2016,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"AbbVie","keywords":"Acetylcholinesterase; Placebo; Medicine; Randomized controlled trial; Acetylcholinesterase inhibitor; Double blind; Disease; Galantamine; Alzheimer's disease; Pharmacology; Internal medicine; Dementia; Donepezil; Alternative medicine; Pathology; Enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002699017,0.001593116,0.004133491,0.0005413856,0.0006904941,0.0008556842,0.0008844403,0.001940219,0.003957322],"category_scores_gemma":[0.002127675,0.0007427162,0.001960517,0.0004947407,0.001101477,0.0008251298,0.000326395,0.001690596,0.000892164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005503907,"about_ca_system_score_gemma":0.001350019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007502493,"about_ca_topic_score_gemma":0.001887797,"domain_scores_codex":[0.9987864,0.000600048,0.0001485438,0.0001981095,0.0001438397,0.0001230005],"domain_scores_gemma":[0.9984366,0.0003178152,0.0004354994,0.0001378601,0.0001991625,0.0004730952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9674249,0.01253269,0.001062441,0.0004570717,0.00067967,0.00004564564,0.00004479104,0.00008791759,0.007224025,0.00002213198,0.0003369798,0.01008183],"study_design_scores_gemma":[0.8239708,0.1672622,0.006464966,0.00002117736,0.0006756652,0.00005585679,0.00001825762,0.0002531791,0.0008550492,0.00003478824,0.0003688423,0.00001909945],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992323,0.002343703,0.0004130765,0.0001988806,0.0002195,0.003043022,0.0006149002,0.00009376041,0.0007499749],"genre_scores_gemma":[0.9928048,0.001307146,0.001184391,0.000450781,0.0003675524,0.002097555,0.000761466,0.00001404057,0.001012208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004133491,"threshold_uncertainty_score":0.01427394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341966113121187,"score_gpt":0.2993117284915029,"score_spread":0.275892067360291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}