{"id":"W2292842767","doi":"10.1161/atvbaha.116.307282","title":"miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux","year":2016,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Cell biology; Oxysterol; Biology; Endosome; Cholesterol; Liver X receptor; microRNA; Gene knockdown; Homeostasis; Nuclear receptor; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004624763,0.0002959001,0.0008006533,0.0001517975,0.0001336031,0.00003082566,0.00009543932,0.0002214236,0.00003856562],"category_scores_gemma":[0.00005568461,0.0001911962,0.0001718211,0.0001120448,0.0003623443,0.0001516515,0.0001273127,0.000115464,0.000007301269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001892454,"about_ca_system_score_gemma":0.00001717067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002803948,"about_ca_topic_score_gemma":0.000008071472,"domain_scores_codex":[0.9982164,0.0001450747,0.0005208603,0.0005609602,0.0001384561,0.0004182313],"domain_scores_gemma":[0.9991186,0.00007422158,0.0002037602,0.000346158,0.00007302326,0.0001841898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000007790616,0.00007134629,0.1355841,0.0001232034,0.0001830608,4.248063e-8,0.0003869942,4.895944e-8,0.8584604,0.00007357431,0.00002190076,0.005087513],"study_design_scores_gemma":[0.003396573,0.0004692695,0.9652805,0.0008920636,0.0002078055,0.000004167088,0.0001297319,0.0000160965,0.02602986,0.00001970703,0.003312221,0.0002420226],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980765,0.0002172888,0.0001327644,0.000803585,0.0001920579,0.0004789502,0.00001464503,0.00005754075,0.00002665774],"genre_scores_gemma":[0.9974927,0.001349135,0.0006564486,0.0002180605,0.0001668545,0.0000426266,0.00001210271,0.0000379352,0.00002412911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8324305,"threshold_uncertainty_score":0.7796754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02408592617694074,"score_gpt":0.2628050378144593,"score_spread":0.2387191116375185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}