{"id":"W2292886270","doi":"10.3233/jhd-159003","title":"Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington’s Disease","year":2015,"lang":"en","type":"review","venue":"Journal of Huntington s Disease","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Quinolinic acid; Kynurenine; Indoleamine 2,3-dioxygenase; Kynurenine pathway; Kynurenic acid; Neuroprotection; Metabolite; Huntington's disease; Neurodegeneration; Tryptophan; Enzyme; Catabolism; Pharmacology; Biochemistry; Disease; Biology; Chemistry; Medicine; Amino acid; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001139546,0.0009706096,0.002362427,0.00133611,0.0001649718,0.0003567106,0.00159922,0.0002665507,0.0004587276],"category_scores_gemma":[0.003583482,0.0007752348,0.001769109,0.001205284,0.00027425,0.0006764771,0.0003351801,0.001479672,0.000282834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076554,"about_ca_system_score_gemma":0.003118742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009124785,"about_ca_topic_score_gemma":0.000001868024,"domain_scores_codex":[0.9931371,0.001079267,0.002198052,0.0009011439,0.001708488,0.0009760173],"domain_scores_gemma":[0.9942899,0.0003632083,0.002552863,0.0007749389,0.0002440218,0.001775105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001893699,0.004235319,0.0002923759,0.01730231,0.0002516741,0.003866622,0.0003023225,0.0001773528,0.0003205531,0.0005555563,0.004083081,0.9667192],"study_design_scores_gemma":[0.00247633,0.0001984118,0.0004816516,0.00804475,0.0006610254,0.00005526792,0.00009886056,0.0000432886,0.0001540031,0.002271273,0.9843339,0.00118125],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01077886,0.9861441,0.00002722264,0.0002432617,0.001103713,0.0009671794,0.00015386,0.00007196233,0.0005098273],"genre_scores_gemma":[0.03150387,0.965246,0.00006896428,0.001022301,0.001154522,0.00004821269,0.00003212579,0.0002332722,0.0006907009],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9802508,"threshold_uncertainty_score":0.9994699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429775877604345,"score_gpt":0.3253923804122192,"score_spread":0.2824147926517848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}