{"id":"W2293119263","doi":"10.1016/j.carres.2016.02.012","title":"Orthoesters formation leading to mismatched Helferich glycosylations at O-3 of N-trichloroacetylated glucosamine residues","year":2016,"lang":"en","type":"article","venue":"Carbohydrate Research","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Orthoester; Glycosidic bond; Glycosyl donor; Residue (chemistry); Stereochemistry; Trisaccharide; Disaccharide; Lewis acids and bases; Glucosamine; Glycosylation; Glycosyl; Bromide; Steric effects; Catalysis; Organic chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009802821,0.0002915493,0.0004626067,0.0004391162,0.0003188938,0.0000633413,0.0005306281,0.0002784591,0.0008279004],"category_scores_gemma":[0.001231904,0.0002310454,0.000164895,0.001504425,0.0002131177,0.0003195319,0.0002750689,0.0002635371,0.0002420558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007437044,"about_ca_system_score_gemma":0.0001298351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006995111,"about_ca_topic_score_gemma":0.00009782898,"domain_scores_codex":[0.9967316,0.0001436812,0.0007172113,0.0005812717,0.0009480525,0.0008782166],"domain_scores_gemma":[0.9967141,0.00108342,0.0001685478,0.0009283745,0.0007025843,0.0004029787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002576168,0.00006328365,0.0007652925,0.0002509833,0.00005677339,0.00002056488,0.0006714186,0.000040774,0.9936646,0.00007849588,0.0006549155,0.003475272],"study_design_scores_gemma":[0.000587829,0.00004071167,0.0001417493,0.0003218993,0.00002488749,0.0000105323,0.0003933204,0.000227443,0.9961227,0.0001515583,0.001679526,0.0002978498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783679,0.0001663509,0.0001363121,0.001287234,0.00005595645,0.0002199028,0.0001021138,0.000130052,0.01953419],"genre_scores_gemma":[0.9915121,0.0001581884,0.000149842,0.00001590868,0.0001424721,0.0001214097,0.00007465347,0.00004910021,0.007776316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01314422,"threshold_uncertainty_score":0.942176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06803312109341893,"score_gpt":0.3287246502701406,"score_spread":0.2606915291767217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}