{"id":"W2293163894","doi":"10.1007/s10295-016-1733-y","title":"Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in<i>Streptomyces clavuligerus</i>","year":2016,"lang":"en","type":"article","venue":"Journal of Industrial Microbiology & Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland; Research and Development Corporation of Newfoundland and Labrador; University of Victoria","keywords":"Streptomyces clavuligerus; Clavulanic acid; Biology; Streptomyces; Streptomycetaceae; Mutant; Biochemistry; Bacteria; Microbiology; Actinomycetales; Gene; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053744,0.0003460215,0.0002469871,0.0003902985,0.0001578775,0.0002865651,0.0001459274,0.0002211843,0.0005039501],"category_scores_gemma":[0.0001247484,0.0001333462,0.0003784349,0.0003444297,0.00015237,0.0002184842,0.0001597377,0.00023987,0.0002344164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272968,"about_ca_system_score_gemma":0.0002096449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265799,"about_ca_topic_score_gemma":0.001145325,"domain_scores_codex":[0.9999133,0.000009638633,0.000007406523,0.00003075369,0.00001904023,0.00001976315],"domain_scores_gemma":[0.9999,0.00001325222,0.0000337722,0.000006261125,0.00001545617,0.00003123302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008108033,0.000007123025,0.0004038497,0.00001920634,0.000003537892,0.00003018201,0.00000839697,0.00002160074,0.999035,0.00001606797,0.00001051293,0.0003633372],"study_design_scores_gemma":[0.00001741981,0.000325184,0.144743,0.00001364801,0.00006068179,0.0006463009,0.0002142536,0.002068811,0.8501055,0.0001061712,0.001680857,0.00001818637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961973,0.000908475,0.001132178,0.00005601504,0.00001267083,0.00001422016,0.0009572612,0.00004266865,0.0006791547],"genre_scores_gemma":[0.9928734,0.0006507421,0.002535063,0.00007581924,0.000008989091,0.00002421635,0.002608894,0.00002232579,0.001200573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265799,"threshold_uncertainty_score":0.002516925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02295387509586793,"score_gpt":0.2494586928198236,"score_spread":0.2265048177239556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}