{"id":"W2293191076","doi":"10.1021/acs.biochem.5b01272","title":"Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer’s Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Helmholtz-Gemeinschaft","keywords":"Sulindac; Chemistry; Fibril; Peptide; Biophysics; Sulfide; Amyloid (mycology); Biochemistry; Pharmacology; Nonsteroidal; Organic chemistry; Biology; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757017,0.000187516,0.0002379757,0.00003513976,0.000118643,0.00001021975,0.0002774133,0.00007551235,0.00008627443],"category_scores_gemma":[0.0005126077,0.00008700349,0.0001946197,0.0003361584,0.0002452818,0.00009875058,0.0001430366,0.0001243125,0.00001535277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004441998,"about_ca_system_score_gemma":0.000438694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002995086,"about_ca_topic_score_gemma":0.000003062568,"domain_scores_codex":[0.9984508,0.00007676041,0.0003487274,0.0002448735,0.0005506957,0.0003281794],"domain_scores_gemma":[0.9982978,0.0001266095,0.0002890731,0.0007354557,0.0002760192,0.0002750402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001066679,0.001044501,0.03207206,0.0003505429,0.001758555,0.0000192284,0.000138804,7.391173e-7,0.9597201,0.00002975472,0.001632311,0.002166694],"study_design_scores_gemma":[0.001312962,0.00006017897,0.05514208,0.000337072,0.000481255,0.000009766272,0.00009390864,0.00001910997,0.9423168,0.00007034048,0.00006576796,0.0000907937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917668,0.004783428,0.000003540831,0.00208938,0.00003924548,0.0005830542,0.0002648584,0.00002333918,0.0004463408],"genre_scores_gemma":[0.9993068,0.000273072,0.0000148213,0.00007754527,0.00009273302,0.00006858625,0.00004449857,0.00001905045,0.0001028678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02307002,"threshold_uncertainty_score":0.3547899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02535352731966826,"score_gpt":0.2954193467973699,"score_spread":0.2700658194777016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}