{"id":"W2293491429","doi":"10.1093/hmg/ddw076","title":"DNA methylation profiling in human Huntington's disease brain","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; CHDI Foundation","keywords":"DNA methylation; Biology; CTCF; Huntingtin; Methylation; Epigenetics; Promoter; Regulation of gene expression; Molecular biology; Genetics; Gene expression; Gene; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756779,0.0002747153,0.0001900788,0.0002306292,0.0002038998,0.00007838339,0.0003995728,0.0000596872,0.00009779373],"category_scores_gemma":[0.0007239977,0.0002440105,0.0001122202,0.0002819461,0.0001868189,0.00007515957,0.0001770529,0.0001054113,0.00005196718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005571798,"about_ca_system_score_gemma":0.00006810627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002575815,"about_ca_topic_score_gemma":0.000008245774,"domain_scores_codex":[0.997328,0.0004905201,0.000398796,0.0008280155,0.0004771671,0.0004775015],"domain_scores_gemma":[0.9987989,0.000112616,0.0001389393,0.0006479202,0.00006131313,0.0002402946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000935367,0.00009975388,0.005675576,0.00001614174,0.000002423833,0.00004531897,0.0000412302,0.0003431362,0.9864064,0.006507273,0.00004655739,0.000806784],"study_design_scores_gemma":[0.0006911528,0.00007015322,0.05642502,0.00003565341,0.00001644371,6.569399e-7,0.000006699239,0.00007595449,0.9346688,0.00747977,0.0002227822,0.0003068656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954405,0.00009528021,0.002618001,0.0004534824,0.00008901997,0.0005275199,0.00002394866,0.00008528808,0.0006669241],"genre_scores_gemma":[0.998095,0.00001098553,0.0003998716,0.0009464114,0.00007483263,0.00006540716,0.00001028114,0.00007196032,0.0003252589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05173761,"threshold_uncertainty_score":0.995046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03180462955821593,"score_gpt":0.3011350215098452,"score_spread":0.2693303919516292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}