{"id":"W2293491429","doi":"10.1093/hmg/ddw076","title":"DNA methylation profiling in human Huntington's disease brain","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; CHDI Foundation","keywords":"DNA methylation; Biology; CTCF; Huntingtin; Methylation; Epigenetics; Promoter; Regulation of gene expression; Molecular biology; Genetics; Gene expression; Gene; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007829396,0.0001248389,0.0002748558,0.0005953895,0.0001662103,0.0001804704,0.00009206357,0.000126895,0.0008461077],"category_scores_gemma":[0.0001554424,0.00008975445,0.0001347618,0.0003644974,0.00007428067,0.0000447926,0.0001482941,0.000135339,0.0001966087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322327,"about_ca_system_score_gemma":0.0001353627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003765099,"about_ca_topic_score_gemma":0.007009863,"domain_scores_codex":[0.9999472,0.000004979041,0.000002716375,0.00002228143,0.00001325386,0.000009517191],"domain_scores_gemma":[0.9999588,0.000007651269,0.000007843665,0.000003134787,0.00001454603,0.000008086963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005421429,0.00001491374,0.0287746,0.0001243853,0.0000973033,0.000160541,0.0002265889,0.0001479115,0.9528208,0.00004891024,0.0002215672,0.01682027],"study_design_scores_gemma":[0.00002654416,0.0002919122,0.8070359,0.00002520612,0.0001983558,0.001534742,0.0002567314,0.001311622,0.1853808,0.0002711278,0.00364743,0.00001944351],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894111,0.003966231,0.002897706,0.00004678141,0.000008413715,0.00002302472,0.002470793,0.0000786125,0.001097393],"genre_scores_gemma":[0.9895207,0.002228759,0.002863954,0.00007690051,0.000007986096,0.00004713816,0.003336775,0.00003015117,0.001887728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003765099,"threshold_uncertainty_score":0.007486403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03180462955821593,"score_gpt":0.3011350215098452,"score_spread":0.2693303919516292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}