{"id":"W2293900604","doi":"10.1158/1557-3125.advbc-pr07","title":"Abstract PR07: Integrative functional genomics of breast cancer","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Synthetic lethality; Biology; CDKN2A; Copy-number variation; Gene; PTEN; Cancer; Cancer research; CDKN2B; Small hairpin RNA; Breast cancer; Genetics; Somatic cell; Palbociclib; Computational biology; Genome; Gene knockdown; Metastatic breast cancer; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002601805,0.0001771654,0.0001879056,0.0001168523,0.00009620467,0.00005477591,0.000304865,0.0001501936,0.001138547],"category_scores_gemma":[0.00007523638,0.0001624904,0.0001264408,0.000227201,0.000266561,0.000007296249,0.0002329158,0.0002788813,0.00004072511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697701,"about_ca_system_score_gemma":0.0008586249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005105114,"about_ca_topic_score_gemma":0.0005441136,"domain_scores_codex":[0.998387,0.00006344086,0.0002607091,0.0004358213,0.0004061445,0.000446926],"domain_scores_gemma":[0.998356,0.00003718734,0.00008566576,0.0004118259,0.000950132,0.000159162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001260456,0.0000805107,0.002235776,0.00003830868,0.0001331987,0.000004062184,0.00005783377,0.0009018382,0.9685079,0.0003320372,0.01778231,0.009800122],"study_design_scores_gemma":[0.0008023764,0.0001787294,0.07119668,0.00007596982,0.00002054884,0.00001008469,0.0002482347,0.0001437142,0.901998,0.0007390933,0.02424718,0.0003393222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904526,0.004552376,0.0006209123,0.001231397,0.0002277191,0.0005020829,0.0003666912,0.000006593199,0.002039664],"genre_scores_gemma":[0.9955031,0.00252781,0.0001791314,0.0002693687,0.000356662,0.0005137934,0.00008232438,0.0000451799,0.0005226502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06896091,"threshold_uncertainty_score":0.9997746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02784823323185618,"score_gpt":0.3337837203843147,"score_spread":0.3059354871524585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}