{"id":"W2293936410","doi":"10.1016/j.celrep.2016.02.051","title":"Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Medical Research Council; Francis Crick Institute; Cancer Research UK; Wellcome Trust","keywords":"Neurotrophin; Cockayne syndrome; Biology; Neurotrophic factors; Ectopic expression; Neuroscience; Brain-derived neurotrophic factor; Cell biology; Genetics; Gene; Xeroderma pigmentosum; DNA repair; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367708,0.0002754742,0.000234753,0.0002500928,0.0002127857,0.0002955542,0.0002327936,0.0004239535,0.001333324],"category_scores_gemma":[0.0001324545,0.0001036961,0.0002208701,0.0001391923,0.0003606659,0.0001953736,0.0002592386,0.0007046148,0.0003059766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000235002,"about_ca_system_score_gemma":0.0003722289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008506638,"about_ca_topic_score_gemma":0.001798898,"domain_scores_codex":[0.9998667,0.00002575153,0.0000249964,0.00002550429,0.00002599105,0.00003102556],"domain_scores_gemma":[0.9999226,0.00001821668,0.00001439511,0.00001073241,0.000006098379,0.00002785654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001397734,0.00006954764,0.0001739201,0.0000533997,0.000008235198,0.0001346578,0.00001400892,0.00006439003,0.9972108,0.0003167971,0.0000611374,0.00175333],"study_design_scores_gemma":[0.00008888743,0.001091368,0.003209449,0.00001408524,0.00002316402,0.000688716,0.00005289237,0.0005794895,0.9903542,0.0001405133,0.003748063,0.000009283346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938724,0.001931773,0.001376384,0.0001916928,0.00006358428,0.00005866106,0.0003207732,0.00009342622,0.002091317],"genre_scores_gemma":[0.9947662,0.001622073,0.002237002,0.00007727647,0.00001142185,0.00005148538,0.0002314193,0.00001334314,0.0009897021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333324,"threshold_uncertainty_score":0.004460394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008235544338750327,"score_gpt":0.2156336910521044,"score_spread":0.207398146713354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}