{"id":"W2293988845","doi":"10.1371/journal.pone.0150943","title":"Deletion of the Toll-Like Receptor 5 Gene Per Se Does Not Determine the Gut Microbiome Profile That Induces Metabolic Syndrome: Environment Trumps Genotype","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Gut flora; Biology; Metabolic syndrome; TLR5; Microbiome; Insulin resistance; Innate immune system; Immunology; Endocrinology; Obesity; Internal medicine; Toll-like receptor; Immune system; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158274,0.0005946272,0.0005411856,0.0007867785,0.0002183638,0.000387766,0.0003304843,0.0006208062,0.003017713],"category_scores_gemma":[0.0002525761,0.0003406323,0.0003852619,0.0003277208,0.0005462325,0.0003832616,0.0005196317,0.0008265718,0.0005592984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419658,"about_ca_system_score_gemma":0.00025722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003975995,"about_ca_topic_score_gemma":0.00109893,"domain_scores_codex":[0.9994977,0.00008463005,0.000072188,0.000152286,0.0001037766,0.0000894675],"domain_scores_gemma":[0.9994007,0.00006976567,0.0002048504,0.00007192737,0.00002701169,0.0002257736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005172482,0.00006129705,0.0008116066,0.00002486985,0.000009501749,0.00009157447,0.00001454549,0.00002457178,0.9976329,0.00009082926,0.00001688594,0.0007042264],"study_design_scores_gemma":[0.0001195037,0.001361639,0.04536407,0.00004328055,0.0000864506,0.001961418,0.0001643284,0.0009431266,0.9473903,0.0002137572,0.00232348,0.00002875769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994903,0.0005530398,0.002776111,0.0001253612,0.00004309752,0.00002703414,0.0007392908,0.00006304741,0.0007701052],"genre_scores_gemma":[0.9920501,0.000593881,0.003099475,0.0001422887,0.00001224464,0.0000767872,0.0008553013,0.0001337734,0.003036099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003017713,"threshold_uncertainty_score":0.0100953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517292641715392,"score_gpt":0.2133132971329267,"score_spread":0.1881403707157727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}