{"id":"W2294075477","doi":"10.1007/s00894-015-2878-8","title":"Molecular assembly of lethal factor enzyme and pre-pore heptameric protective antigen in early stage of translocation","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Modeling","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Health Sciences Centre; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Compute Canada","keywords":"Anthrax toxin; Histone octamer; Protein subunit; Biophysics; Endosome; Chemistry; Conformational change; Molecular dynamics; Toxin; Chromosomal translocation; Membrane; Biochemistry; Receptor; Biology; Fusion protein; Recombinant DNA; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008267925,0.0002834034,0.0002108175,0.0001367472,0.000455658,0.0005215918,0.0003730201,0.0003519699,0.003454889],"category_scores_gemma":[0.000205171,0.0002765568,0.0002718271,0.0001010796,0.0002858584,0.0007403106,0.0002107227,0.0006347504,0.0005432335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006042643,"about_ca_system_score_gemma":0.0004213296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001594816,"about_ca_topic_score_gemma":0.0007517665,"domain_scores_codex":[0.9999548,0.000002904736,0.000001387708,0.00001054771,0.000007015797,0.00002327323],"domain_scores_gemma":[0.9999486,0.000008299748,0.00001064712,0.000005096268,0.000007718867,0.00001957747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001041101,0.0003636403,0.004976181,0.0002259397,0.00004042918,0.001446252,0.0004830051,0.08371524,0.8496644,0.0471732,0.001204824,0.009665664],"study_design_scores_gemma":[0.000198297,0.0005416349,0.006405434,0.00002333818,0.00004195103,0.0004170868,0.0004774626,0.5583955,0.4181808,0.0105325,0.004719344,0.00006660796],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780367,0.0002098297,0.01596669,0.0002550058,0.00005294135,0.00003858193,0.0001200664,0.0002414567,0.005078731],"genre_scores_gemma":[0.9923131,0.0001368393,0.004259929,0.00002494554,0.000005498769,0.00002646045,0.0001656782,0.00003174309,0.003035827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003454889,"threshold_uncertainty_score":0.01155776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860559459924709,"score_gpt":0.2894400631794829,"score_spread":0.2608344685802358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}