{"id":"W2294124032","doi":"10.1073/pnas.1521990113","title":"Models for the a subunits of the <i>Thermus thermophilus</i> V/A-ATPase and <i>Saccharomyces cerevisiae</i> V-ATPase enzymes by cryo-EM and evolutionary covariance","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Thermus thermophilus; ATPase; Protein subunit; V-ATPase; Biology; F-ATPase; ATP synthase gamma subunit; Saccharomyces cerevisiae; Biochemistry; ATP hydrolysis; ATP synthase; AAA proteins; Enzyme; Yeast; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444592,0.0004967641,0.000361804,0.0003726963,0.0007557163,0.00082646,0.001080269,0.001204915,0.001586425],"category_scores_gemma":[0.0003299746,0.0004653128,0.0007173585,0.000358187,0.0006076727,0.001086088,0.0004613223,0.000575794,0.000721721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008925616,"about_ca_system_score_gemma":0.0008315357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002426705,"about_ca_topic_score_gemma":0.002070565,"domain_scores_codex":[0.9999191,0.00001942449,0.000006106144,0.00002186845,0.00002494703,0.000008667399],"domain_scores_gemma":[0.9998969,0.00001992989,0.00002855838,0.00001239208,0.00001400062,0.00002825836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004980167,0.0001754673,0.004822639,0.0005927294,0.0001653245,0.001120663,0.001036388,0.4819745,0.2299891,0.2571911,0.00261754,0.01981653],"study_design_scores_gemma":[0.000124314,0.0001690467,0.002866668,0.00008584651,0.00004916323,0.0003623754,0.0002908768,0.8796953,0.01450002,0.08428234,0.01751187,0.00006221408],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7630513,0.004138296,0.2130347,0.001283512,0.0001078796,0.00008522799,0.0005210979,0.0007954967,0.01698252],"genre_scores_gemma":[0.9488387,0.001982993,0.04491564,0.0001001208,0.00002265057,0.0001624045,0.0009921255,0.0001222132,0.002863204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002426705,"threshold_uncertainty_score":0.006476045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03116692639351739,"score_gpt":0.2892674579954763,"score_spread":0.2581005316019589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}