{"id":"W2294124032","doi":"10.1073/pnas.1521990113","title":"Models for the a subunits of the <i>Thermus thermophilus</i> V/A-ATPase and <i>Saccharomyces cerevisiae</i> V-ATPase enzymes by cryo-EM and evolutionary covariance","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Thermus thermophilus; ATPase; Protein subunit; V-ATPase; Biology; F-ATPase; ATP synthase gamma subunit; Saccharomyces cerevisiae; Biochemistry; ATP hydrolysis; ATP synthase; AAA proteins; Enzyme; Yeast; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007897553,0.000103295,0.0001220198,0.00002844574,0.0002863564,0.00001774228,0.0006784413,0.00008280073,0.000003746168],"category_scores_gemma":[0.0004275606,0.00004426185,0.00007267746,0.0002086663,0.001375639,0.00004652721,0.0002759619,0.00006622266,8.660777e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007095784,"about_ca_system_score_gemma":0.00005829504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006525097,"about_ca_topic_score_gemma":2.00226e-7,"domain_scores_codex":[0.9988348,0.00001686566,0.0002201746,0.0002529225,0.0005195222,0.0001557384],"domain_scores_gemma":[0.9991633,0.0002315016,0.0002780615,0.00002692624,0.0002659176,0.000034275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006980755,0.00002907838,0.0008323981,0.00005951214,0.00003108578,2.819641e-9,0.00005442358,0.00001765209,0.9842972,0.009359483,0.003608653,0.001640726],"study_design_scores_gemma":[0.0004474861,0.0001022386,0.003891858,0.0001313095,0.00002558235,0.000007434177,0.0001820904,0.0007305909,0.969044,0.0230778,0.002257262,0.0001022929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837922,0.006500998,0.00004118536,0.008711825,0.0000122897,0.0003861557,0.0002662913,0.000002808114,0.0002862842],"genre_scores_gemma":[0.9980149,0.001048349,0.0002253468,0.0003321181,0.00007221174,0.00003198773,3.457435e-7,0.000006157156,0.0002685422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01525313,"threshold_uncertainty_score":0.5068601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03116692639351739,"score_gpt":0.2892674579954763,"score_spread":0.2581005316019589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}