{"id":"W2294162426","doi":"10.1186/s12967-016-0814-z","title":"PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma","year":2016,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Government of Ontario; Ontario Institute for Cancer Research","keywords":"PI3K/AKT/mTOR pathway; Doxorubicin; Pharmacology; Protein kinase B; In vivo; Cancer research; Medicine; Leiomyosarcoma; Chemotherapy; Cell growth; Chemistry; Biology; Signal transduction; Internal medicine; Pathology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004946283,0.0001525766,0.0004129088,0.0003686566,0.00003963456,0.000004919791,0.00003530083,0.00006675923,0.0001386216],"category_scores_gemma":[0.00005369409,0.00007471871,0.0001123773,0.0001865036,0.00008911546,0.000259498,0.000001486199,0.0001010673,0.000001709341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001128433,"about_ca_system_score_gemma":0.0000857175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001625947,"about_ca_topic_score_gemma":0.00001858993,"domain_scores_codex":[0.9986467,0.00006543537,0.0004735311,0.0001564858,0.0005103882,0.0001474305],"domain_scores_gemma":[0.9985679,0.0005555486,0.0002351898,0.00009901648,0.0004146972,0.0001276183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01569505,0.004443852,0.4158245,0.0001020758,0.0006340597,0.0003387593,0.002881574,0.00002182151,0.06633995,0.002307334,0.001320746,0.4900903],"study_design_scores_gemma":[0.06017523,0.01524269,0.8873124,0.00187499,0.0002227121,0.0005074759,0.000124989,0.00008493155,0.02835879,0.004317843,0.001647228,0.0001306965],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9435203,0.001358404,0.004760147,0.04925555,0.0001070173,0.0008950247,0.0000137052,0.000008364905,0.00008148586],"genre_scores_gemma":[0.9969323,0.0001767326,0.001577352,0.0008079916,0.0003794681,0.00005947363,0.00002372526,0.00002023674,0.00002271217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4899596,"threshold_uncertainty_score":0.304694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644309749728969,"score_gpt":0.3095652228694276,"score_spread":0.2831221253721379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}