{"id":"W2294169926","doi":"10.1053/j.ackd.2016.01.013","title":"Drug Disposition Issues in CKD: Implications for Drug Discovery and Regulatory Approval","year":2016,"lang":"en","type":"review","venue":"Advances in Chronic Kidney Disease","topic":"Pharmaceutical Economics and Policy","field":"Economics, Econometrics and Finance","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Lawson Health Research Institute","funders":"","keywords":"Medicine; Kidney disease; Drug; Intensive care medicine; Pharmacokinetics; Adverse effect; Hemodialysis; Population; Pharmacology; Diabetes mellitus; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006189197,0.0005418254,0.002573267,0.002099117,0.0002859475,0.002523997,0.001171377,0.002859879,0.004449618],"category_scores_gemma":[0.01198154,0.0003210546,0.001123178,0.003622126,0.001571845,0.003087334,0.001069174,0.003481394,0.000478528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00265461,"about_ca_system_score_gemma":0.005630954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003865069,"about_ca_topic_score_gemma":0.008088017,"domain_scores_codex":[0.9984576,0.0007283768,0.0001796603,0.0001508035,0.0003962337,0.00008740366],"domain_scores_gemma":[0.9871675,0.01070871,0.001092441,0.0001342501,0.0007472385,0.0001497951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002313107,0.000152032,0.001555529,0.02291051,0.0005596057,0.0003157704,0.00007747066,0.00457544,0.0002891047,0.1105149,0.0305058,0.8283126],"study_design_scores_gemma":[0.000162508,0.000185973,0.006852497,0.03417766,0.00099159,0.00159535,0.0003090121,0.002877151,0.0004573486,0.1815673,0.7707278,0.00009582188],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002438214,0.9926259,0.000528776,0.00540913,0.0001868732,0.000003483352,0.00003305259,0.000002913574,0.0009660678],"genre_scores_gemma":[0.0055212,0.9915484,0.0005647096,0.001352897,0.0007107707,0.000007779467,0.00002334894,0.000002045,0.0002688533],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006189197,"threshold_uncertainty_score":0.03273201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03579520739453439,"score_gpt":0.3592444941319362,"score_spread":0.3234492867374018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}