{"id":"W2294534146","doi":"10.1016/j.bpj.2015.11.588","title":"Cellular Pathophysiology of “MHH”, A Large Group of Patients with Equivocal Diagnosis of Malignant Hyperthermia","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Malignant hyperthermia; Medicine; RYR1; Caffeine; Pathophysiology; Internal medicine; Muscle biopsy; Ryanodine receptor; Biopsy; Calcium; Physiology; Pathology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002309689,0.0002452511,0.0004437374,0.0005536547,0.0005210795,0.0005316992,0.0002665226,0.0004176867,0.001666329],"category_scores_gemma":[0.001459391,0.0001077951,0.0001510313,0.0003648437,0.0005580253,0.0003530409,0.0005782058,0.0003270416,0.000293856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466184,"about_ca_system_score_gemma":0.0002606681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003497005,"about_ca_topic_score_gemma":0.0002485297,"domain_scores_codex":[0.9998098,0.00003788405,0.00002046551,0.00003838077,0.00003425847,0.00005927631],"domain_scores_gemma":[0.9995595,0.0001182453,0.0001331013,0.00004410971,0.0000406536,0.0001044212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001216239,0.0000728119,0.9259198,0.00008423891,0.00006116944,0.02532391,0.0004999602,0.000182488,0.02868194,0.001081295,0.0008246287,0.01605149],"study_design_scores_gemma":[0.00002933967,0.0003083177,0.9370342,0.00001899728,0.00004076138,0.05635356,0.0008082936,0.0005915227,0.002284336,0.001113377,0.001402823,0.00001444592],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976433,0.0006864991,0.0002996409,0.0002815202,0.00001705913,0.00001415129,0.00008859506,0.000009100529,0.0009602488],"genre_scores_gemma":[0.9996324,0.00009371771,0.00006504662,0.00003852209,0.0000419044,0.000003894806,0.00007837961,0.000001285811,0.00004483197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666329,"threshold_uncertainty_score":0.005574465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006989127888472896,"score_gpt":0.2060920145190142,"score_spread":0.1991028866305413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}