{"id":"W2294537429","doi":"10.1038/ncomms10784","title":"Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; European Commission; Genentech; Wellcome Trust","keywords":"Wnt signaling pathway; Cell biology; Biology; Embryonic stem cell; Stem cell; Haematopoiesis; Dorsal aorta; Bone morphogenetic protein; Zebrafish; Mesonephros; Anatomy; Neuroscience; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002064085,0.0001168557,0.0001676926,0.0001742359,0.0001024954,0.000006911592,0.001046613,0.0002498549,0.00002056428],"category_scores_gemma":[0.0004547191,0.00008968238,0.00006950212,0.0005180031,0.0003442756,0.000009315261,0.0004747876,0.0003460574,0.00001475096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006055419,"about_ca_system_score_gemma":0.0002478695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008413851,"about_ca_topic_score_gemma":0.0001387831,"domain_scores_codex":[0.9987825,0.0001278948,0.0004452408,0.0002184761,0.0002525212,0.0001733598],"domain_scores_gemma":[0.9975637,0.0004705708,0.0002472319,0.000989295,0.0006128445,0.0001164171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001662838,0.0002767942,0.0002560777,0.00001524544,0.0001223671,6.256212e-8,0.00009580969,2.42876e-7,0.9795823,0.0009430228,0.004597607,0.01409386],"study_design_scores_gemma":[0.0003274804,0.00006137841,0.0003047011,0.00008590687,0.00001538984,0.000001492057,0.000220604,0.00003046504,0.9473072,0.00008844974,0.05144388,0.0001130014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7883208,0.007163625,0.180187,0.01337073,0.0003439061,0.00200397,0.001445222,0.00009458815,0.007070052],"genre_scores_gemma":[0.9896237,0.0007393883,0.009030632,0.0000835205,0.0000135734,0.0001025546,0.0002095721,0.00001692426,0.0001801231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2013029,"threshold_uncertainty_score":0.3657141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01736353431127863,"score_gpt":0.3202774755849804,"score_spread":0.3029139412737017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}