{"id":"W2294569491","doi":"10.1038/ncomms10827","title":"Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Alberta Innovates; Wellcome Trust","keywords":"Intermediate filament; Vimentin; Cytoskeleton; Intermediate Filament Protein; Cell biology; Plasma protein binding; Biology; Biophysics; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005183587,0.0001499056,0.00008665147,0.00006849573,0.0001318659,0.0001966034,0.0002059862,0.000194664,0.0006617974],"category_scores_gemma":[0.00007326015,0.00009416619,0.0001508738,0.00003911737,0.0001835026,0.0001846657,0.0001703084,0.0002652321,0.0002112842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897997,"about_ca_system_score_gemma":0.00008620025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002582606,"about_ca_topic_score_gemma":0.000324013,"domain_scores_codex":[0.9999461,0.000009204639,0.000002484484,0.0000144716,0.00001347203,0.00001426539],"domain_scores_gemma":[0.9999635,0.00000504404,0.00001316494,0.000004033035,0.000003733963,0.00001056578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003533077,0.000006193754,0.0003686019,0.000009788729,0.000002688078,0.0001396902,0.00001875203,0.0001421297,0.9985486,0.0002572584,0.00001454913,0.0004563842],"study_design_scores_gemma":[0.00001878249,0.0001291452,0.00777806,0.000004903683,0.00001073885,0.0009211801,0.00009625987,0.004221749,0.9853868,0.0002568668,0.001167321,0.000008144922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969472,0.0001171798,0.002072406,0.00003570424,0.000003834133,0.000005085246,0.00001672656,0.00002175497,0.0007801056],"genre_scores_gemma":[0.9988385,0.00005581344,0.0006768457,0.00001145802,9.499438e-7,0.000002048223,0.00002153839,0.000002219943,0.0003906325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006617974,"threshold_uncertainty_score":0.002213895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115260260956213,"score_gpt":0.2831593942453811,"score_spread":0.2716333681497597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}