{"id":"W2294721676","doi":"10.1021/acs.jmedchem.5b01740","title":"Tryptic Stability of Synthetic Bactenecin Derivatives Is Determined by the Side Chain Length of Cationic Residues and the Peptide Conformation","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of Tehran; Iran National Science Foundation","keywords":"Chemistry; Isothermal titration calorimetry; Trypsin; Peptide; Cationic polymerization; Stereochemistry; Side chain; Cleavage (geology); Lysine; Amino acid; Residue (chemistry); Peptide synthesis; Arginine; Enthalpy; Cyclic peptide; Enzyme; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162094,0.000196861,0.0001408339,0.0001360407,0.00007406218,0.0002155773,0.0001289151,0.0001623824,0.0005386542],"category_scores_gemma":[0.000400274,0.00008490548,0.00009164803,0.0001390355,0.0002427898,0.0001412374,0.00009835428,0.0002953885,0.000117862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602619,"about_ca_system_score_gemma":0.0001184825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002726881,"about_ca_topic_score_gemma":0.0003219846,"domain_scores_codex":[0.9998887,0.00002592958,0.00000944588,0.00002066143,0.00003156913,0.0000237921],"domain_scores_gemma":[0.9996437,0.0001228542,0.00009752043,0.00001878574,0.00004161844,0.00007556377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007987637,0.000005987798,0.0002442856,0.00001435207,0.000002440916,0.0000154163,0.000008383207,0.00006668189,0.9989598,0.00001633724,0.00000243133,0.0005840363],"study_design_scores_gemma":[0.000005848884,0.0002980287,0.003042902,0.000003540018,0.000006961266,0.0001080966,0.00001533407,0.0003740633,0.9958655,0.0000183068,0.0002575937,0.000003772835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983602,0.0004063295,0.0008080457,0.00001011072,0.000002403221,0.00000844185,0.00005838608,0.00000761579,0.0003384257],"genre_scores_gemma":[0.9983765,0.0002352309,0.0009555968,0.00001369348,0.000001745365,0.000008699024,0.0001708406,0.00000556522,0.0002320456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005386542,"threshold_uncertainty_score":0.001801968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00876407530253781,"score_gpt":0.2162726723372542,"score_spread":0.2075085970347164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}