{"id":"W2294823670","doi":"10.1038/bcj.2016.9","title":"Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial","year":2016,"lang":"en","type":"article","venue":"Blood Cancer Journal","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Deutsche Forschungsgemeinschaft; National Cancer Institute; Celgene","keywords":"IGHV@; Lenalidomide; Internal medicine; Chronic lymphocytic leukemia; Oncology; Medicine; Refractory (planetary science); Hematology; Fludarabine; Gastroenterology; Leukemia; Multiple myeloma; Chemotherapy; Biology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003808248,0.000799509,0.001172124,0.0002190693,0.0002346548,0.0009350231,0.000727497,0.0007341746,0.00124522],"category_scores_gemma":[0.002128981,0.0002820166,0.0009415784,0.0004307418,0.0004768703,0.0004623318,0.0003380039,0.001266882,0.000271604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000669125,"about_ca_system_score_gemma":0.0006940508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008240992,"about_ca_topic_score_gemma":0.002095995,"domain_scores_codex":[0.9987187,0.00097588,0.00006852522,0.00009116132,0.00008924802,0.0000563212],"domain_scores_gemma":[0.9980742,0.0005915604,0.0007453464,0.000143007,0.00007592613,0.0003700134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8386451,0.004057979,0.07292911,0.00073996,0.00303171,0.00011232,0.0001224974,0.001863934,0.006022417,0.0001632447,0.003072149,0.06923955],"study_design_scores_gemma":[0.6011909,0.1272046,0.2486508,0.0003339252,0.005054695,0.0006695766,0.0001389669,0.003912193,0.003105321,0.0005014988,0.009145427,0.00009209265],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988444,0.008683773,0.0001592637,0.0004069389,0.00004359162,0.0002196102,0.001231625,0.00002642791,0.0007848173],"genre_scores_gemma":[0.9924936,0.002224308,0.0005017979,0.0004497339,0.00009684802,0.0003247923,0.003379717,0.00001126273,0.0005178973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003808248,"threshold_uncertainty_score":0.02014017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05766062988039832,"score_gpt":0.3618330372027641,"score_spread":0.3041724073223657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}