{"id":"W2295210936","doi":"10.1039/c6dt00446f","title":"Heteroleptic arene Ru(<scp>ii</scp>) dipyrrinato complexes: DNA, protein binding and anti-cancer activity against the ACHN cancer cell line","year":2016,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"","keywords":"Cancer; Cancer cell lines; Chemistry; DNA; Cell culture; Cancer cell; Cancer research; Cell; Molecular biology; Biochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002344044,0.0003059441,0.0004637018,0.00009198672,0.0006843933,0.00005253244,0.0001609542,0.00010887,0.0002961277],"category_scores_gemma":[0.00003168777,0.0001666118,0.0001712422,0.0001784138,0.000242294,0.000268024,0.00002516961,0.0002704729,0.00002491778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255974,"about_ca_system_score_gemma":0.00008677764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005551157,"about_ca_topic_score_gemma":0.0005716785,"domain_scores_codex":[0.9983864,0.0001311381,0.0003051966,0.0004341225,0.0003079082,0.000435207],"domain_scores_gemma":[0.998967,0.0001960756,0.0001360504,0.0004264117,0.00008669859,0.0001877481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005325016,0.000219448,0.000359512,0.0001969885,0.000126871,0.000002073916,0.000387654,0.00002329616,0.9753461,0.00001879566,0.00008624454,0.0231798],"study_design_scores_gemma":[0.001060978,0.0002193455,0.003114368,0.0004502849,0.0002049265,0.000008651603,0.0002075995,0.0003585036,0.970437,0.00002281048,0.02377395,0.0001415835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901712,0.001663573,0.003176133,0.002760901,0.0001824181,0.0008127158,0.0003308762,0.0001083007,0.0007938803],"genre_scores_gemma":[0.989125,0.002160484,0.0001286437,0.0002480296,0.000147502,0.0004189789,0.000006799726,0.00005066461,0.007713886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02368771,"threshold_uncertainty_score":0.6794232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04463305221327978,"score_gpt":0.2743890689129939,"score_spread":0.2297560166997141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}