{"id":"W2295641663","doi":"10.1128/jvi.03010-15","title":"DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biology; Virus; Viral life cycle; Virology; Influenza A virus; Stress granule; Helicase; RNA Helicase A; Immunoprecipitation; VP40; Ribonucleoprotein; Viral matrix protein; Viral replication; Cell biology; RNA; Gene; Genetics; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009632233,0.0003250067,0.0001849141,0.0001079808,0.0003134517,0.0002503144,0.0001477194,0.0002768177,0.001795028],"category_scores_gemma":[0.00008016847,0.00008182681,0.0003204305,0.0001222781,0.0002164144,0.0001883945,0.0002873879,0.0002324422,0.0003528676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003978697,"about_ca_system_score_gemma":0.0001054754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003476428,"about_ca_topic_score_gemma":0.000387427,"domain_scores_codex":[0.9999212,0.0000107454,0.000007886792,0.00002486376,0.00001724225,0.00001798155],"domain_scores_gemma":[0.9999441,0.000007800738,0.0000187674,0.000005000525,0.000007237064,0.00001710409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001994876,0.00001417344,0.001523146,0.00006797628,0.00001061435,0.00009992905,0.00001833242,0.00003451451,0.9968426,0.00005581491,0.00006483961,0.001068637],"study_design_scores_gemma":[0.00003640667,0.0001476782,0.06011446,0.00001465653,0.00002765393,0.0008923993,0.00007400857,0.001631358,0.9322813,0.0001455377,0.004627349,0.000007186574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913933,0.003802653,0.002898092,0.0001503978,0.00004734408,0.00002261213,0.0004702031,0.00007530219,0.001140016],"genre_scores_gemma":[0.9945019,0.0008111675,0.001703326,0.00006756072,0.00001797025,0.00002442557,0.0007167873,0.00001562393,0.002141115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795028,"threshold_uncertainty_score":0.00600493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083615244857169,"score_gpt":0.2620385446002168,"score_spread":0.2512023921516451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}