{"id":"W2295694156","doi":"10.1111/mmi.13348","title":"Signaling by the heavy‐metal sensor CusS involves rearranged helical interactions in specific transmembrane regions","year":2016,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Krell Institute; Division of Chemistry; Health and Medical Research Fund; Health Canada","keywords":"Biology; Transmembrane protein; Transmembrane domain; Computational biology; Cell biology; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000879337,0.0002760857,0.0001385095,0.00009918233,0.0001752843,0.0002026223,0.0001072864,0.0002125764,0.0003395723],"category_scores_gemma":[0.00007660779,0.00009537334,0.0001808499,0.0001032204,0.000237419,0.0001895415,0.0001645505,0.0002369179,0.0001930123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466473,"about_ca_system_score_gemma":0.0001546807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005265624,"about_ca_topic_score_gemma":0.0005665614,"domain_scores_codex":[0.9999123,0.00001656773,0.000005887316,0.0000200114,0.00002347065,0.00002184945],"domain_scores_gemma":[0.9999466,0.000007772273,0.00002235614,0.000004582419,0.000008038117,0.00001062715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002661956,0.000003296273,0.0002669383,0.000007965901,0.00000116933,0.00004136466,0.00001041499,0.00004682333,0.9992095,0.00006849511,0.000007570154,0.0003098748],"study_design_scores_gemma":[0.000006791051,0.0001029295,0.006784812,0.000003538081,0.00000833291,0.000334354,0.00006828058,0.001573051,0.9903381,0.00009034586,0.0006840178,0.000005247588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980593,0.0002103404,0.001382997,0.00003754512,0.000004064831,0.000005071246,0.0000369868,0.0000249811,0.0002386967],"genre_scores_gemma":[0.9985346,0.0001263142,0.0008796891,0.00001637523,0.000002334724,0.000003630916,0.00006240873,0.00000427753,0.0003704631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005265624,"threshold_uncertainty_score":0.00178951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334482863886313,"score_gpt":0.2306785747956168,"score_spread":0.2173337461567536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}