{"id":"W2295759421","doi":"10.1002/jcp.25337","title":"Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates <i>MCL1</i> Pre‐mRNA Splicing","year":2016,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Cancer Society","keywords":"H3K4me3; Demethylase; Exon; Histone; Acetylation; Nucleosome; Histone H3; MCL1; RNA splicing; Chromatin; Biology; Molecular biology; Alternative splicing; Cell biology; Cancer research; Gene; Gene expression; Genetics; Promoter; RNA; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006831432,0.0001390076,0.0001380161,0.0001090768,0.0001253523,0.0002738838,0.0001605415,0.0001433475,0.001379506],"category_scores_gemma":[0.00007199895,0.0001124536,0.000219,0.00007461448,0.0001619659,0.0001248363,0.0001282117,0.0002859358,0.0003319258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003255752,"about_ca_system_score_gemma":0.0001423763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002609088,"about_ca_topic_score_gemma":0.00364219,"domain_scores_codex":[0.9999226,0.000006319005,0.000003897476,0.00001840944,0.00001809876,0.00003054411],"domain_scores_gemma":[0.9999526,0.000006818741,0.00001530122,0.000004449671,0.000007339172,0.00001352522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006919431,0.000005545724,0.0005732932,0.00001179193,0.000003527178,0.00001101162,0.000006778065,0.00003603553,0.9987034,0.00002866743,0.00002538786,0.0005253341],"study_design_scores_gemma":[0.000007968003,0.00008205485,0.0280753,0.000003012603,0.000009466535,0.0000735455,0.00002180914,0.0007027535,0.969893,0.00002450358,0.00110209,0.000004510495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958947,0.001203958,0.001102342,0.00006187118,0.00001926888,0.000007017381,0.0002549154,0.00007017646,0.001385806],"genre_scores_gemma":[0.9981619,0.0002788281,0.0003476735,0.00003003652,0.000003456883,0.000004562572,0.0002320065,0.000007776073,0.0009338162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002609088,"threshold_uncertainty_score":0.00518775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005407725150944274,"score_gpt":0.2541215272017092,"score_spread":0.2487138020507649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}