{"id":"W2295759421","doi":"10.1002/jcp.25337","title":"Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates <i>MCL1</i> Pre‐mRNA Splicing","year":2016,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Cancer Society","keywords":"H3K4me3; Demethylase; Exon; Histone; Acetylation; Nucleosome; Histone H3; MCL1; RNA splicing; Chromatin; Biology; Molecular biology; Alternative splicing; Cell biology; Cancer research; Gene; Gene expression; Genetics; Promoter; RNA; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003502816,0.0001386426,0.0003295941,0.0001085509,0.00004811041,0.000005374881,0.0002826522,0.0001560121,0.00004925151],"category_scores_gemma":[0.0001204551,0.00009420118,0.0002065557,0.00006975507,0.0001634944,0.00001545225,0.00009513663,0.0001230161,0.000007328572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003939989,"about_ca_system_score_gemma":0.00009216243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009197073,"about_ca_topic_score_gemma":0.000004785205,"domain_scores_codex":[0.9987032,0.0001298319,0.0005020967,0.0001941495,0.0001934562,0.0002772317],"domain_scores_gemma":[0.9987767,0.00004437786,0.0005144025,0.0003045943,0.0002549951,0.0001049019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004097591,0.00006089533,0.0002740801,0.00003104425,0.00008700536,0.000005073744,0.00002450221,0.00009766753,0.9942347,0.00004958635,0.0002811597,0.004444575],"study_design_scores_gemma":[0.0009951605,0.0009072158,0.007147155,0.00007070817,0.00002254116,0.00004673464,0.00001743058,0.0002209813,0.9882059,0.0007113147,0.001532082,0.0001227412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943405,0.001292487,0.003753292,0.0002807688,0.0001591302,0.00008464458,0.000005082351,0.000003600056,0.00008050694],"genre_scores_gemma":[0.9971671,0.0005523404,0.0007398941,0.00004716766,0.0002050847,0.000001427166,0.000009269363,0.0000224441,0.001255291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006873074,"threshold_uncertainty_score":0.3841413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005407725150944274,"score_gpt":0.2541215272017092,"score_spread":0.2487138020507649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}