{"id":"W2295777772","doi":"10.2174/1874467209666160112125446","title":"Mevalonate Cascade and Neurodevelopmental and Neurodegenerative Diseases: Future Targets for Therapeutic Application","year":2016,"lang":"en","type":"review","venue":"Current Molecular Pharmacology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Mevalonate pathway; Neuroprotection; Neurodegeneration; Neuroscience; GTPase; Small GTPase; Biology; Signal transduction; Medicine; Bioinformatics; Pharmacology; Cell biology; Disease; Internal medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005199829,0.000972782,0.001694861,0.001221746,0.0002453187,0.001250678,0.0007779288,0.001211687,0.005015112],"category_scores_gemma":[0.0003933479,0.0002680092,0.0005133792,0.001213034,0.0005347489,0.001510323,0.0008920425,0.002261228,0.00229802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004886609,"about_ca_system_score_gemma":0.001492021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006481681,"about_ca_topic_score_gemma":0.001822979,"domain_scores_codex":[0.9998761,0.00002032286,0.00002234402,0.00002386245,0.00003847769,0.00001891952],"domain_scores_gemma":[0.9998291,0.00006029276,0.00003366218,0.000005572913,0.00004498067,0.00002651712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004375741,0.0001688006,0.0002330088,0.01449501,0.000174246,0.0003816418,0.0000609325,0.0003390543,0.004922862,0.003879847,0.02675885,0.9481481],"study_design_scores_gemma":[0.0001477342,0.0003243905,0.001001218,0.003544546,0.0003908459,0.001463774,0.0001235865,0.0002141448,0.001234084,0.004525994,0.9869879,0.00004174708],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001578063,0.9984175,0.0001590685,0.0004164796,0.0002176229,0.000004948365,0.00001936166,0.000009764201,0.0005973799],"genre_scores_gemma":[0.0009469799,0.9977247,0.0002886808,0.0002561358,0.0002512593,0.00000725985,0.00003266498,0.000001141582,0.0004912237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005015112,"threshold_uncertainty_score":0.01677722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548360180108766,"score_gpt":0.371601383834584,"score_spread":0.3461177820334963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}